Analysis Of Outcomes And Related Factors Of In Vitro Fertilization And Embryo Transfer In Patients With Ovarian Endometriosis Accompanied By Infertility

ObjectiveIn this study,the ovarian utero is explored by comparing the stages of in vitro fertilization-embryo transfer(IVF-ET)and the outcomes of infertility in women with infertility in ovarian endometriosis(OEMC)and infertile individuals with tubal infertility.The effect of membrane ectopic cysts on in vitro fertilization-embryo transfer is expected to provide clinical guidance.Materials and MethodsRetrospective analysis Clinical data of infertile women with complete medical records who received IVF-ET in the Reproductive Medicine Center of the Third Affiliated Hospital of Zhengzhou University,Henan Province during the period from 2008.01 to 2016.07.According to the medical history,the ovarian endometriotic cyst group(study group)and the simple fallopian tube factor infertility group(control group)were included.Collection of medical records includes general information,ovulation induction,laboratory conditions,and follow-up information.(1)Inclusion criteria: Before the woman entered the cycle,diagnosed as ovarian endometrioma cyst with infertility / tubal factor infertility alone,study group: patients who had undergone ovarian endometriotic cystectomy without relapse;Control group: Infertile IVF-ET patients due to fallopian tube factors(laparoscopically confirmed tubal obstruction alone),age,body mass index(BMI),infertility in the study group The principle of matching age and promotion plan is selected in about 1:3.(2)Exclusion criteria: 1 The woman suffers from polycystic ovary syndrome(PCOS);2 The woman suffers from an abnormal uterus anatomy or disease(such as uterine septum);3 Both men and women suffer from chromosomal abnormalities;4 In addition to the history of ovarian surgery beyond endometriosis surgery;5 clinically confirmed patients with adenomyosis(AM)or ultrasound examination showed increased uterine evenness and uneven echo.(3)Analyze the clinical data of the two groups and compare the general conditions including age,infertility period,body mass index(BMI),antral follicle count,and basal endocrine,ovulation drug initiation dose and ovulation stimulation time.The total dose of ovulation-promoting drugs,the number of mature follicles,the number of oocytes obtained,the number of 2PN,the number of high quality embryos,the implantation rate and the miscarriage rate,the clinical pregnancy rate,the live birth rate,etc.(4)Use the SPSS21.0 statistical software package to process the collected data.P < 0.05 difference was statistically significant.Results(1)A total of 352 oviposition cycles in patients with ovarian endometriosis cysts were included in the study group,and 1059 oviposition cycles in patients with tubal infertility alone.The age,infertility,and body mass index of the women in the two groups(There were no statistical differences between the general data groups such as BMI and ovulation induction(P>0.05).(2)The antral follicle number(AFC),the number of mature follicles,the number of oocytes retrieved,the number of 2PN(normal fertilization),the number of good embryos,and the rate of high-quality embryos in the study group were significantly lower than those in the control group(P<0.05).There was no significant difference in the normal fertilization rate and cleavage rate between the two groups(P>0.05).There was no significant difference in Gn initiation volume and Gn total days between the two groups,but the total Gn study group was higher than the control group(P).<0.05)(3)There was no significant difference in implantation rate,biochemical pregnancy rate,clinical pregnancy rate,early abortion rate,late abortion rate and live birth rate between the two groups(P>0.05).(4)Clinical pregnancy was used as a dependent variable(clinical pregnancy = 1,no pregnancy = 0).The clinical data of the two groups were divided into subgroups based on whether clinical pregnancy was used or not,and were analyzed using a two-factor multivariate logistic regression model.The OEMC group showed a statistically significant difference in age(OR=0.905,95% CI: 0.849-0.964)and number of mature follicles on day hCG(OR=1.037,95%CI:0.937-1.150)(P<0.05).Conclusions(1)Ovarian reserve in ovarian endometriosis patients undergoing IVF fertility treatment declines,and it affects oocyte maturation,egg quality,and embryo quality(2)Ovarian endometriosis has no significant relationship with normal fertilization rate,clinical pregnancy rate and miscarriage rate.(3)The number of mature follicles in hCG is a protective factor for clinical pregnancy in infertile patients with OEMC.