Expressions And Clinical Significance Of Angiopoietin And The Receptor-Tie2 In Kawasaki Disease

Objective: To test the expression level of TEK receptor tyrosine kinase-Tie2(Tie2),Angiopoietin 1(Angpt1)、Angiopoietin 2(Angpt2)in plasma specimens in Kawasaki Disease(KD)of different stages,so to discuss the relationship of Tie2,Angpt1,Angpt2 levels and KD and the probable vascular infusion mechanism in KD.Methods: We collected a total number of 79 of KD cases which were diagnosed and treated in cardiology department in Children’s Hospital of Suzhou University from years 2017 to 2018.At the same time,we set two control groups-febrile control group and none-infection control group,respectively with20 cases and 18 cases.The levels of Tie2,Angpt1,Angpt2 in different specimens were detected by Enzyme-Linked immunosorbent assay(Elisa).At the same time,we evaluated the condition of the coronary arteries via the Doppler Heart Ultrasound machine,and collected several relevant laboratory data of all the cases(Creactive protein,erythrocyte sedimentation rate,platelet count,hemoglobin value,serum albumin value,albumin transaminase,white blood cell count,urine sediment count,in all.).All these data above were analyzed statistically to evaluate the results.Results: 1.The Tie2 level of plasma in KD teams is much lower than that of none-infection control groups(p=0.48),but with no difference with febrile control group.2.The plasma Tie2 level was lower in patients of KD before intravenous immunoglobulin treatment(before IVIG)than that in KD patients after intravenous immunoglobulin treatment(after IVIG)(p=0.007).3.The plasma Tie2 level of patients with KD coronary artery lesion(CAL)was lower than that of none-CAL(p=0.033).4.Compare with the two control groups,the Angpt1 level decreases significantly in KD group(p=0.003,p=0.039).5.Compare with the two control groups,the Angpt2 level rises significantly in KD group(p=0.007 p=0.001).6.Angpt1 level shows a rising tendency though KD IVIG treatment,while Angpt2 shows a adverse decreasing tendency(p=0.001,p=0.001).7.Angpt1 and Angpt2 level in KD with or without CAL,in complete KD or incomplete KD,in IVIG-sensitive KD or insensitive KD,show no difference.Conclusion: Plasma Tie2,Angpt1,Angpt2 levels significantly changed in the group of KD group than control groups,suggesting that Angpt/Tie2 axis is effective in the pathologic progression of KD.Secondly,the level of Tie2,Angpt1,Angpt2 increased significantly in the stage(after IVIG),indicating that they can be used to observe the therapeutic effect.At the same time,comparing the KD cases with and without with CAL,we can see that Tie2 and Angpt1 are related to the severity of KD.That is to say Angpt/Tie2 axis may play an important role in the occurrence of kawasaki disease and the process of coronary artery injury.In conclusion,Tie2,Angpt1,Angpt2 shows significant variation in KD,and may have certain value in predicting the occurrence of coronary artery injury and long prognosis of KD.