Effects Of Irbesartan Tablets And Nifedipine Controlled Released Tablets On Cytokines And Immune Function In Primary Hypertensive Patients

Objective:To discuss the mechanism of Irbesartan Tablets and Nifedipine Controlled Released Tablets affecting the inflammatory status of primary hypertensive patients by observing the effects of Irbesartan Tablets and Nifedipine Controlled Released Tablets on the cytokines interleukin-10(IL-10),interleukin-17(IL-10),immune function and otherindicatorsin primary hypertensive patients.Methods:120 primary hypertensive patients treated at the cardiovascular internal medicine department of Xinhua Hospital Affiliated to Dalian University from July 2016to December 2017 were selected as the hypertension group,which were randomly divided into Irbesartan group(n=60)that took Irbesartan Tablets for antihypertensive treatment and Nifedipine group(n=60)that took Nifedipine Controlled Released Tablets for antihypertensive treatment;70 healthy controls in the corresponding period were selected as the control group.The systolic pressure,diastolic pressure,pulse pressure,heart rate and other situations of the three groups were monitored.The enzyme-linked immunosorbent assay was used to detect the cytokines IL-10 level and IL-17 level of the three groups,and the flow cytometry was used to determine CD4~+level,CD8~+level,and CD4~+/CD8~+ratio immune indicator of the Irbesartan and Nifedipine groups before and after treatment.The cytokines IL-10 level and IL-17 level in the hypertensive patients and healthy controls were compared;the cytokines IL-10level and IL-17 level of the two treatment groups were also compared,observing the effects of Irbesartan Tablets and Nifedipine Controlled Released Tablets on the cytokines IL-10 and IL-17 in the patients.The immune indicator,clinical efficiency and adverse drug reactions of the two treatment groups were compared.Results:1.The effects of Irbesartan Tablets and Nifedipine Controlled Released Tablets on blood pressure and heart rate of the patients:there was no statistic difference in the comparison of systolic pressure,diastolic pressure,pulse pressure and heart rate between the two treatment groups before and after treatment(P>0.05).After treatment,there was no statistic difference in the comparison of pulse pressure of the patients between the two treatment groups(P>0.05);the systolic pressure and diastolic pressure of the patients in the Irbesartan group were significantly higher than that in the Nifedipine group(P<0.05);the heart rate of the patients in the Irbesartan group was significantly lower than that in the Nifedipine group(P<0.05).2.The effects of Irbesartan Tablets and Nifedipine Controlled Released Tablets on the cytokines in the patients:there was difference between the cytokine levels in the patients of the hypertension group and the control group,in which the cytokine IL-10level was lower than that of the control group(P<0.05)and the cytokine IL-17 level was higher than that of the control group(P<0.05);there was no statistic difference in the comparison of the cytokines IL-10 level and IL-17 level between the two treatment groups(P>0.05).After treatment,the cytokine IL-10 level in the patients of the two treatment groups was significantly higher than that before treatment(P<0.05);the cytokine IL-17 level in the patients of the two treatment groups was significantly lower than that before treatment(P<0.05);at the second,fourth,sixth and eighth weeks after treatment,the cytokine IL-10 levels in the patients of the Irbesartan group were significantly higher than that of the Nifedipine group(P<0.05)while the cytokine IL-17levels in the patients of the Irbesartan group were significantly lower than that of the Nifedipine group(P<0.05).3.The effects of Irbesartan Tablets and Nifedipine Controlled Released Tablets on the immune indicator in the patients:before treatment,there was no statistic difference in the comparison of the immune indicator of the two treatment groups(P>0.05).At the eighth week of treatment,the CD4~+level and CD4~+/CD8~+ratio of the Irbesartan group and Nifedipine group were significantly lower than that before treatment(P<0.05)while the CD8~+level of the Irbesartan group and Nifedipine group was significantly higher than that before treatment(P<0.05).At the eighth week of treatment,the CD4~+level and CD4~+/CD8~+ratio of the Irbesartan group were significantly lower than that of the Nifedipine group(P<0.05),while the CD8~+level in the patients of the Irbesartan group was significantly higher than that of the Nifedipine group(P<0.05).4.Adverse drug reactions:8 weeks of treatment,the incidence of adverse drug reactions of the Irbesartan group was 5.00%,and there was no statistic difference comparing to 7.50%of the Nifedipine group(P>0.05).5.The correlation of the cytokines with blood pressure and immunity in primary hypertensive patients:the cytokine IL-10 level had a significantly negative correlation with systolic pressure,diastolic pressure,and immune level(P<0.05);the cytokine IL-17 level had a significantly positive correlation with systolic pressure,diastolic pressure,and immune level(P<0.05).Conclusion:1.The use of Irbesartan Tablets and Nifedipine Controlled Released Tablets in primary hypertensive patients can effectively control the blood pressure,increase the cytokine IL-10 level,decrease the cytokine IL-17 level,and regulate the body's immunity.2.The Irbesartan Tablets can better inhibit inflammatory response and regulate the body's immune status than Nifedipine Controlled Released Tablets.