Cardiopulmonary Exercise Test In Children With Remission Of Asthma

Objective: To investigate the differences of cardiopulmonary exercise test?CPET?between children with Remission of asthma and normal children,And the children with asthma remission in the routine treatment at the same time,add to a certain intensity of aerobic exercise-based program of exercise,to compare the cardiopulmonary exercise test and pulmonary function indicators and non-exercise group differences.Methods: 100 children aged 7-14 years were collected for basic information such as sex,age,height,weight,body mass index and static pulmonary function test.100 children included asthma remission group?50 cases?and healthy control group?50cases?.At the same time,cardiopulmonary exercise testing system was used to test cardiopulmonary exercise in these children according to the standard CPET protocol.In addition,asthmatic children with asthma remissions are randomly grouped according to whether or not they undergo aerobic exercise on the basis of the original treatment.After3 months of follow-up,collect static pulmonary function test and cardiopulmonary exercise testing again.The detection indexes included the maximal oxygen uptake?VO₂max/kg?,oxygen uptake at anaerobic threshold?VO₂/ kg @ AT?,maximal tolerance power?Pmax?,maximal heart rate?HRmax?,FEV1% Pred,MMEF Pred,FEF50% Pred and FEF75% Pred were measured and compared.Results:1.VO₂/kg@AT,VO₂max/kg,Pmax and HRmax in the asthma remission group were?16.53±5.25?ml/?min·kg?,?26.10±7.89?ml/?min·kg?,?68.94±10.16?W,?164.00±14.13?beats per minute.Children in the healthy control group had VO₂/kg@AT,VO₂max/kg,Pmax and HRmax were?20.11±3.98?ml/?min·kg?and?31.74±6.09?ml/?min·kg?,?89.31±20.49?W,?181.81±11.40?beats/min,the above indicators in the asthma remission group compared with the healthy control group decreased significantly,the difference between the two groups was statistically significant?P all< 0.05?.2.Asthma remission period group FEF 75% of predicted value percentage,FEF50% percentage of predicted value,and MMEF percentage predictedvalue were 58.65±18.44,74.06±17.08,69.48±14.01,respectively,FEF 75% of predicted percentage of children in healthy control group,The percentage of predicted FEF50%and predicted MMEF were: 73.76±11.83,85.76±7.79,and 81.85±6.96.Compared with the healthy control group,the above-mentioned indexes in the asthma remission group decreased,and the difference between the two groups was statistically significant?P all<0.05?.3.Before the treatment of children with exercise group VO₂/kg@AT,VO₂max/kg,Pmax,HRmax,FEV1% Pred,FEF75% Pred,FEF50% Pred,MMEF Pred detection indicators were:?17.80±6.18?ml/?min·kg?,?26.83±8.17?ml/?min·kg?,?68.63±10.41?W,?164.50±9.97?beats/min,92.47±9.66,58.63±18.46,76.07±14.71,74.01±17.69;3 months after treatment,VO₂/kg@AT,VO₂max/kg,Pmax,HRmax,FEV1% Pred,FEF75% Pred,FEF50% Pred,and MMEF Pred were:?19.95±2.46?ml/?min·kg?,?30.21±5.78?ml/?min·kg?,?71.88±9.31?W,?165.25±17.77?beats/min,93.78±9.35,60.77±18.29,76.31±13.57,75.60±16.44.After the treatment,the above indicators were detected more than before treatment,and the difference was statistically significant?P all<0.05?.4.The indexes of VO₂/kg@AT,VO₂max/kg,Pmax,HRmax,FEV1% Pred,FEF75% Pred,FEF50% Pred,and MMEF Pred before treatment in the non-exercise group were?16.26±3.75?ml/?min·kg?,?25.36±7.42?ml/?min·kg?,?69.25±10.02?W,?163.50±18.11?beats/min,88.92±16.11,59.66±19.45,72.05±20.00,65.03±7.67.After 3 months of treatment,the VO₂/kg@AT,VO₂max/kg,Pmax,HRmax,FEV1% Pred,FEF75% Pred,FEF50% Pred,and MMEF Pred indicators were:?16.55±4.12?ml/?min·kg?,?25.59±6.63?ml/?min·kg?,?69.88±10.21?W,?165.31±9.80?beats/minute,89.43±15.91,59.82±18.19,73.41±19.59,66.48±7.59.After the treatment,the above indicators were detected more than before treatment,and the difference was statistically significant?P all<0.05?.5.Compared with the non-exercise group,the VO₂/kg@AT?19.95±2.46 ml/?min·kg??in the exercise group was significantly higher in the exercise group and the non-exercise group?16.55±4.12?ml/?min·kg?,The increase was statistically significant?P <0.05?.The VO₂max/kg?30.21±5.78?ml/?min·kg?in exercise group was higher than that in non-exercise group?25.59±6.63?ml/?min·kg?.The difference was statistically significant?P <0.05?.6.Compared with the non-exercisegroup,the FEV1% Pred,FEF50% Pred,FEF75% Pred,and MMEF Pred were higher in the exercise group and the non-exercise group after 3 months,but the difference was not statistically significant.?P all>0.05?.Conclusion: 1.The difference between the remission of asthma children and healthy children in FEF75% Pred,FEF50% Pred,MMEF Pred,suggesting that the impact of asthma on children's small airway function.2.Cardiopulmonary exercise testing can detect the overall state of oxygen uptake during exercise,more responsive to static lung function,reflecting an improvement in overall cardiopulmonary function.3.The difference between the remission of asthma children and healthy children in VO₂max/kg,VO₂/kg@AT,HRmax,Pmax suggests that asthma may have some influence on the cardiopulmonary function of children.4.Aerobic exercise was performed on the basis of conventional asthma recovery treatment,and VO₂max/kg and VO₂/kg@AT were compared with those in children who did not receive routine aerobic exercise,suggesting that cardiopulmonary exercise testing may the beneficial effects of aerobic exercise on cardiopulmonary overall function during asthma remission were detected during exercise.For patients with remission of asthma in the original treatment at the same time with exercise prescription can improve their overall cardiopulmonary function and promote their cardiopulmonary function as soon as possible.