Clinical Research Of A Patient With Talaromyces Marneffei And Other Complex Infectiondue To Anti-IFN-γ Antibody

Objective We report a case of dessimated Talaromyces marneffei and non tuberculous Mycobacterium,other bacteria,and herpes zoster infections due to anti-IFN-γ autoantibodies.A new type of immune deficiency syndrome,which has not been paid attention to.A newer clinician was updated on non HIV Talaromyces marneffei.Improve the level of diagnosis and treatment of Talaromyces marneffei disease.Methods The blood and clinical data of the patient,IFN-γ antibody(-)and HIV(-)patients with Talaromyces marneffei and other opportunistic infections were collected,the cases of HIV(-)and Talaromyces marneffei were collected by Pub Med,and the data of different cases were analyzed.The clinical features of IFN-γ antibody(+)and IFN-γ antibody(-)patients were compared,especially the clinical characteristics of IFN-γ antibody(+)combined with Talaromyces marneffei,and the effects of the relative titer and function changes on the condition and prognosis of the patients with Talaromyces marneffine were investigated by design experiments.Results The IFN-γ antibody is present in the serum of patients in this study and has strong functional activity.The clinical features of IFN-γ antibody combined with Talaromyces marneffei were characterized by fever of unknown origin,swelling of the lymph nodes and the susceptibility to Mycobacterium tuberculosis.The patients with IFN-γ antibody are longer,more difficult,and poor in prognosis than those with negative interferon,and the titer and function of IFN-γ antibody in the patients reflect the patient’s change to a certain extent.Conclusion Patients with Talaromyces marneffei caused by IFN-γantibody(+),are susceptible to other opportunistic infections including bacteria,fungi and viruses.The titer and functional changes of IFN-γ antibody affect the patient’s condition at a certain level.Clinicians should update the awareness of the epidemiology and diagnosis of the Talaromyces marneffei baskets.For non HIV Talaromyces marneffei patients,IFN-γ antibodies should be screened,integrated treatment,and detection of antibody titers when necessary.