Comparisons Of Complications Related To Heparin-coated And Non-coated Tunnel Cuffed Catheters

Purpose:To compare the differences in catheter-related complications during the clinical use of heparin-coated and non-coated tunnel cuffed catheters and to determine if heparin-coated catheters are superior to the non-coated tunnel cuffed catheters.Method:60 patients with tunnel cuffed catheters in our hospital were enrolled from September 2015 to March 2017,and patients in my study were divided into heparin-coated and non-coated catheters according to the type of catheter.Patients enrolled in the study would be followed for one year.The sex,age,primary disease,place of insertion,and biochemical index(coagulation function,platelet count etc.)were recorded.Coagulation function and platelet count were detected after three months of catheterization.The number of catheters with catheter dysfunction,thrombolytic accumulative times and accumulative times of hemodialysis were recorded every three months.The jugular veinultrasonography was performed regularly every three months to record the two groups of mural thrombosis.The number of catheters forming thrombosis around the tip of the catheter and the position of the catheter tip were recorded;catheter-related infections,the number of cases of thrombolysis by intravenous drip through catheter,and the patency of thrombolysis were recorded within one year of catheterization.The differences in catheter-related complications between the two groups were compared.Statistical methods:SPSS 24 statistical software was used.Measurement data were expressed as mean ± standard deviation or median(interquartile range).Comparisons between groups were performed using t test or Mann-Whitney U rank sum test;The enumeration data was represented by a constituent ratio or rate,and comparisons between groups were performed using chi-square test or Fisher's exact test,and the p value is less than 0.05 with statistical significance.Results:1.There were no significant differences between the two groups in the general data,including age,sex,primary disease composition,placement site,hemoglobin and albumin.No significant differences were found in prothrombin time,partial activated thromboplastin time,international normalized ratio,and platelet count between two groups before catheterization and the use of catheters for 3 months(P>0.05).2.There were statistically significant differences in the rate of mural thrombosis at the first 3 months between two groups(38.71%,79.31%;P<0.05).It was found that there were no statistically significant differences in the rate of thrombosis around the tip of the catheter in all periods and the rate of mural thrombosis at other periods between two groups(P>0.05).3.There were significant differences in the rate of thrombolysis(12.9%,37.93%;P<0.05)and catheter dysfunction(3.36%,9.67%;P<0.05)between the two groups when the indwelling catheters are used within 3 months.No significant differences were found between the two groups in the rate of thrombolysis and catheter dysfunction at other observation periods.4.There was no significant difference in infection rates between the two groups within one year(P>0.05).Conclusion:1.The heparin coated catheter is safe to use.2.Heparin coated catheter is better than uncoated catheter in 3 months after catheterization.