Effect And Prognostic Analysis Of BCL-2 On Non-muscle Invasion Bladder Cancer

Objective:By examining the expression of BCL-2 in non-muscle-invasive bladder cancer,the role of BCL-2 in the recurrence progression of non-muscle-invasive bladder cancer patients was explored.Methods: A total of 230 patients with MIBC admitted to our hospital from March 2010 to March 2017 were collected.HE staining was used to screen for cases of non-muscle-invasive bladder cancer.Immunohistochemical technique was used to detect the expression of BCL-2 positive and negative in tissue samples from patients with non-muscle-invasive bladder cancer.The patients were followed-up periodically to observe the recurrence and progress of this type of patients.The role of BCL-2 expression in postoperative recurrence and progression of non-muscle-invasive bladder cancer was analyzed and compared.Results: The results of HE staining showed 159 patients with non-muscle invasive bladder cancer and 71 patients with muscular invasive bladder cancer.The recurrence rate was statistically significant in the immunohistochemical BCL-2 positive group compared with the BCL-2 negative group(χ2=3.914,P=0.048),and the progression rate was not statistically significant(χ2=2.707,P=0.100).The rate of relapse and non-progression was statistically significant(χ2=11.160,P=0.001).The overall survival rate of the two groups was compared(χ2=4.482,P=0.034),and the difference was statistically significant.Conclusions: BCL-2-positive patients with non-muscle invasive bladder cancer recurrence rate was high.