The Analysis Of Risk Factors On Nosocomial Infection Of Hematonosis Patients

Objective:Nosocomial infection(NI)causes prolonged hospital stays,increased healthcare costs,and higher mortality among patients with hematological malignancies(HM).Our study went to compare the incidence of NI according to the type of HM lineage,and identify the risk factors for NI.Methods:In this retrospective study,1376 patients with hematonosis disease who were admitted to the Zhongda Hospital affiliated to the Southeast University,were enrolled during 2016.Patients included in the nosocomial infection group were all comformed to relevant regulations published by Ministry of Health in 2001.Information collected from the patients includes name,gender,age,hospitalization record,diagnosis,hospital stay,as well as the information on chemotherapy,number of granulocyte and invasive procedures.All analyses were performed with the Statistical Package for the Social Sciences(SPSS),then the risk factors on nosocomial infection of hematonosis patients were discussed.The article also sums up the form of nosocomial infection,makes modest prognosis and puts forward possible innovative replied measures.Results:This study included 1,376 admissions from the whole patients in hematology department of Zhongda hospital in 2016.During these admissions,230 acquired nosocomial infection,with an attack rate of 27.83%.Higher infection rates were observed among the old admissions,compared to the young admissions(24.86%vs.37.14%,P<0.05).Nosocomial infection attack rates in malignancy disease were higher than those in nonmalignant disease(30.82%vs.10.13%,P=0.000).Divide patients with length of hospital stay into 4 groups(1-10d,11-20d,21-40d,more than 40d),the attack rates rised in turn(6.32%vs.20.98%vs.51.7%vs.75%,P between goups were less than 0.05).Higher infection rates were observed among the patients with agranulocytosis more than 10 days,compared to the the patients with agranulocytosis less than 10 days(47.15%vs.74.22%,P<0.05).Infection sites include upper respiratory tract,lungs,alimentary canal,urinary tract,mouth,skin,soft tissue and blood.The infection in the upper respiratory tract occupied first place,which is 28.46%,followed by pulmonary infection'with 25.59%.There were also many patients with alimentary canal(15.67%)and blood infection(6.53%).Multivariable regression analysis indicated old age,prolonged hospitalization,agranulocytosis less than 10 days,chemotherapy and invasive procedures were independently associated with nosocomial infection.Conclusion:The conclusion of this study showed that old age,prolonged hospitalization,agranulocytosis less than 10 days,chemotherapy and invasive procedures were independently associated with nosocomial infection.To shorten the hospitalization time and agranulocytosis time,less invasive operation may be the effective methods to prevent the acquired hospital infection.