Combination Of Intensive Radiotherapy And Chemotherapy Combined With Recombinant Human P53 Adenovirus Injection In The Treatment Of Stage ⅡB-ⅢB Cervical Squamous Cell Carcinoma

Objective:To analyze the clinical efficacy of intensity modulated radiotherapy combined with chemotherapy combined with recombinant human P53 adenovirus injection in the treatment of cervical squamous cell carcinoma of stageⅡB toⅢB.Methods:Chose stageⅡB toⅢB cervical squamous cell carcinoma in 47 patients,were randomly divided into observation group and control group,observation group were given intratumoral injection of recombinant adenovirus P53 injection 1²×10¹²VP,72h for intensity-modulated radiotherapy and chemotherapy,Since the frist day,cisplatin40mg/m² intravenous drip was given every 7 days.The control group were treated with recombinant human P53 adenovirus injection.Other treatments were same in the two groups.At the end of 8 weeks after treatment,the recent curative effect was evaluated,and quantitative analysis of the change of DNA ploidy index before and after radiotherapy in two groups were compared.Results:The recent rate of control,Observation group 24 cases,CR 15 cases（62.5%）;PR 7 cases（29.1%）;CR+PR is 91.6%;The control group of 23 cases,CR 9 cases（39.1%）;PR 8 cases（34.8%）;CR+PR is 73.9%;the difference was statistically significant（P<0.05）the treatment,the observation group was significantly better than the control group.In the two groups of patients after the treatment,the quantitative analysis of the DNA was performed,and the difference between the observation group and the control group was statistically significant.Conclusions:According to the results of our study,local advanced cervical squamous cell carcinoma patients treated by intensity-modulated radiotherapy and chemotherapy,combined with recombinant human P53 adenovirus injection received better clinical efficacy.Long term follow-up was needed.