Prognostic Analysis Of Interventional Occlusion And Drug Therapy For Patent Foramen Ovale Combined Wiht Ischemic Stroke

Background:Patent foramen ovale(PFO)closure has emerged as a secondary prevention option in patients with PFO and cryptogenic stroke.However,the comparative efficacy and safety of percutaneous closure and medical therapy in patients with cryptogenic stroke and PFO remain unclear.Objective:To retrospectively analyze the clinical features and manifestations of PFO patients,and to explore the prognosis of PFO intervention and drug therapy.Methods:610 cases of cryptogenic stroke were analyzed from the physical examination department of our hospital,and 96 cases of positive(medium and severe)patients were selected and divided into 14 cases in the operation group and 82 cases in the mcdication group.The follow-up investigation was carried out for 3 months,6 months and 12 months.Statistical analysis was carried out by SPSS 19 software package.The experimental data were expressed in the form of standard deviation of average number.The difference was compared between the case group and the normal control group.The significant difference was analyzed by t test and compared between the two groups of cerebral apoplexy,the recurrence rate of TIA and the mortality rate.Results:1.Two groups of patients were followed up for 3 months,6 months and 12 months.The recurrence rate of stroke in the operation group and the drug group was compared.The operation group was followed up for 3 months,6 months and 12 months without recurrent stroke.The group followed up for 3 months of stroke recurrence 0 cases,followed up 6 months of 6 months recurrence of stroke recurrence I cases,followed up 12 months of stroke recurrence 1 cases,none of the differences of all groups were no difference.Significant statistical significance(P>0.05).2.Two groups of patients were followed up for 3 months,6 months and 12 months.Compared with the recurrent stroke or TIA rate in the operation group and the drug group,the operation group was followed up for 3 months,6 monhs and 12 months without recurrence TIA,and the drug group was followed up for 3 months with 0 TIA recurrence,and 6 months of follow-up 6 months of recurrence 0 cases,followed up for 12 months,TIA recurred 1 cases,none of the differences of the groups were no obvious unification.Study significance(P>0.05).3.The two groups were followed up for 3 months,6 months and 12 months.The mortality of the operation group and the drug group was compared The operation group was followed up for 3 months,6 months and 12 months without death.The drug group was followed up for 3 months and died 0 cases,followed up 6 months and 0 cases,and followed up for 12 months.The difference was not statistically significant(P>0.05).4.During the follow-up period of 12 months,7 patients(50%)had complete remission migraine,6 patients had partial remission migraine(42.9%),and no significant change was found in 1 patients(7.1%).Conclusion:1.There was no statistically significant difference in the incidence of complex outcome between PFO intervention and recurrent ischemic stroke,TIA and death.The deficiency of this experiment is that the number of cases is insufficient,relatively short,and the follow-up time is short,but the overall trend is close to the statistical results at home and abroad.2.After 12 months follow-up,patients with patent foramen ovale complicated with ischemic stroke were treated with interventional occlusion.Patent occlusion of patent foramen ovale was effective in relieving migraine.But the mechanism for alleviating migraine is not clear...