The Efficacy And Safety Of Entecavir And Adefovir Dipivoxil In The Treatment Of Chronic Hepatitis B

Backgroud It is well known that chronic hepatitis B(CHB)is one of the most common diseases in the world and can cause about 1 million deaths from chronic hepatitis B-related cirrhosis and hepatocellular carcinoma each year.Antiviral treatment is chronic hepatitis B treatment key.Antiviral treatment of CHB patients first of all to achieve immunological control of HBV,thereby preventing the further development of the disease.For patients with HBe Ag-positive CHB,obtaining HBe Ag seroconversion means achieving immune control.Clinical anti-hepatitis B virus drugs mainly include nucleic acid analogs(NAs)and interferon(IFN).Due to interferon efficacy by host and virus many factors,and the more obvious side effects thus limiting its clinical use.Nucleos(t)ide analogues(NAs)are the major anti-hepatitis B virus drug classes.Entecavir(ETV)and adefovir dipivoxil(ADV)are two nucleotide analogues that are widely used in China.Comparing entecavir Ten-year efficacy and safety of adefovir dipivoxil(ADV)monotherapy in the treatment of chronic hepatitis BMethods In January 2007 to December 2008,we analyzed the clinical datas of 82 cases of patients with a chronic hepatitis B in our hospital,and they were randomly divided into experimental group(ETV,n=50)and control group(SOC,n=32).and the changes of HBV-DNA,HBs Ag and so on were further observed in our study.Results :The negative rate of HBV-DNA after 48 weeks,2-years,3-years,4-years,5-years,6-years,7-years,8-years and 9-years in ETV groups were higher than the SOC group(P<0.05).The negative conversion ratio of Hbe Ag in ETV groups were higher than the SOC group after 10 years of therapy(84.0% vs 71.9%,P<0.001).There was no statistically significant difference of serum conversion rate of Hbe Ag between two groups(64% vs 50.0%,P>0.05).No cirrhosis and liver cancer occurred in both groups.Conclusion :Long-term use of nucleoside analogues is conducive to delaying the progress of HBe Ag-positive chronic hepatitis B,and is conducive to obtaining HBe Ag seroconversion..The negative rate negative and conversion ratio of Hbe Ag of HBV-DNA of ETV was higher than ADV.