| BackgroundIn recent years,as people’s living standard has improved,life style has become more staticthe,and the development of aging population,the prevalence of chronic diseases such as Type 2 Diabetes Mellitus(T2DM),fatty liver disease,and sarcopenia have been increasing year by year.Type 2 diabetes is one of the most important diseases that endanger human health in the world today.There are many pathogenesis of T2DM,of which β cell dysfunction and insulin resistance are the two main aspects.Non-alcoholic fatty liver disease(NAFLD)refers to a clinical pathological syndrome characterized by excessive fat deposition in liver cells caused by some factors excepting alcohol consumption and other factors known to cause liver damage.The incidence of NAFLD has been increasing year by year.Now it has become one of the most common chronic liver diseases in China,and some uncontrolled NAFLD patients can further progress to cirrhosis and even liver cancer.Diabetes and non-alcoholic fatty liver disease have many common pathogenesis.Therefore,it is very necessary to systematically study the factors related to the occurrence of non-alcoholic fatty liver disease in patients with type 2 diabetes.In recent years,researches on sarcopenia have become a hot topic.Sarcopenia refers to a reduction in the amount of skeletal muscle related to aging and/or a decrease in muscle strength or a decrease in muscle physiological function.The study found that there is a correlation between skeletal muscle mass and the occurrence of NAFLD,but this conclusion is controversial,and the specific relationship and the relevant mechanisms have not been completely clear.Further research is needed to confirm it.Objective1.To compare the clinical features of patients with type 2 diabetes in NAFLD group and control group(non-NAFLD group).2.To compare the difference of metabolic factors between NAFLD group and control group,focusing on the relationship between skeletal muscle mass and NAFLD in patients with type 2 diabetes.3.Multivariate logistic regression analysis was used to investigate the independent risk factors and protective factors of NAFLD in patients with type 2 diabetes.MethodsSelecting T2DM patients who were hospitalized in the Department of Endocrinology of the Second Hospital of Shandong University.A total of 166 patients were enrolled.According to the NAFLD diagnostic criteria,all patients enrolled were divided into two groups:the NAFLD group(79 cases)and the control group(non-NAFLD group)(87 cases).Collecting other clinical data of the patients,including gender,age,duration of diabetes and so on.Patient’s blood pressure,heart rate,body mass index,waist-to-hip ratio,visceral fat area,and skeletal muscle mass index were measured.Patient’s blood was collected to determine some indicators such as glucose,glycated hemoglobin,alanine aminotransferase,aspartate aminotransferase,albumin,uric acid,cystatin C,triglyceride,total cholesterol,low density lipoprotein,high density lipoprotein,TSH,25-OH-VitD3,calcium,phosphorus and parathyroid hormone.SPSS 19.0 software was used for data analysis.Result1.A total of 166 patients with T2DM were enrolled,including 79 patients in the NAFLD group and 87 patients in the control group.There was no significant difference in age,gender,duration of diabetes,blood pressure,and heart rate between the two groups,but the body weight,BMI,and waist-hip ratio of the NAFLD group were significantly higher than the control group.2.Alanine aminotransferase,aspartate aminotransferase,albumin,uric acid,triglycerides,high-density lipoprotein,25-OH-VitD3,calcium levels,visceral fat area and height-corrected skeletal muscle mass index(SMI)were significantly different between two groups when using single factor analysis.3.Multivariate logistic regression analysis found that abdominal obesity,albumin,triglyceride levels and height-corrected SMI were independent risk factors for non-alcoholic fatty liver disease with type 2 diabetes.Conclusion1.Obese patients with type 2 diabetes are at high risk of developing nonalcoholic fatty liver disease.Compared with the control group,NAFLD group has higher body weight,body mass index(BMI)and waist-hip ratio.2.Alanine aminotransferase,aspartate aminotransferase,albumin,uric acid,triglycerides,high-density lipoprotein(HDL-C),25-OH-VitD3,calcium levels and visceral fat area,height-corrected SMI are associated with the development of nonalcoholic fatty liver disease in type 2 diabetes.Alanine aminotransferase,aspartate aminotransferase,albumin,uric acid,triglycerides,25-OH-VitD3,and visceral fat area,height-corrected SMI are positively correlated with it.HDL-C and calcium ion are negatively associated with it.3.Albumin,triglyceride levels,abdominal obesity,and height-corrected SMI are independent risk factors for nonalcoholic fatty liver disease in type 2 diabetes patients. |
