| Background: primary hepatic carcinoma,a malignant tumor originating in the epithelial tissue of the liver,hepatocellular carcinoma(HCC)is the most common type of liver cancer.Several hundred thousand of people die of liver cancer or its complications each year.Therefore,prevention,early detection and treatment of HCC is an imminent task to improve the overall survival rate and reduce the incidence of complications.Objective: Through the study of the relationship between the ratio of neutrophils to lymphocyte and the occurrence or development of liver cancer,we hope to provide a new way of thinking for clinical work.Methods: Review of clinical data from January 2013 to December 2014 in patients with primary liver cancer of our hospital,a total of 123 patients with primary liver cancer were included,there were 97 men(78.9%)and 26 women(21.1%).Age 24~78 years(54±11).All patients have preoperative informed consent,operation risk disclosure,comply with ethical requirements.NLR was calculated according to the patient’s first admission peripheral venous blood results,The patients were followed up with RFS,OS and other related clinical data.Make ROC curves of the relationship between recurrence time and NLR in patients with tumors,calculation Youden index.According to the maximum Youden index,patients were divided into high NLR group and low NLR group.Comparison of two groups of age,gender,AFP,PLT,ALT,AST,GGT,ALB,TBIL,and the diameter of tumor,intraoperative bleeding volume,histological differentiation and other related data.Clinical data of the two groups were compared using the χ2 test,Kaplan-Meier and log-rank test method using survival analysis,The prognosis analysis was analyzed by COX regression model.Results: Finally,the critical value of NLR was determined by 2.86,with the sensitivity of 83.6% and the specificity of 53.3%.Comparison of clinical data between high NLR patients and low NLR patients,NLR are associated with TBiL,ALB,and tumor diameter(χ2=6.309,4.005,8.717;p <0.05).Patients of NLR > 2.86 and NLR≤2.86,OS or RFS with log-rank test p< 0.05,has statistical significance.High NLR,AFP>400ng/ml,portal vein tumor thrombus,tumor diameter greater than 5cm were independent prognostic factors in patients with HCC(P< 0.05).Conclusion: It was similar to tumor diameter,AFP level,portal vein tumor thrombus and other tumor related factors,high NLR is an independent risk factor for the prognosis of HCC patients,and the individualized treatment of high NLR patients should be paid attention. |
