The Research Of Lung Cancer With COPD Phenotype And Quantitative Evaluation By Multi-slice Spiral CT

Part I The variance analysis of imaging and clinical features between lung cancer with COPD and simple lung cancerObjective:We use multi-slice spiral CT scan imaging phenotype diagnosis to patients with COPD,to investigate the relationship between the radiographic phenotype COPD and lung cancer classification,providing the basis of curative effect and prognosis judgments for lung cancer.Materials and methods:We retrospectively analyze 99 cases of patients diagnosed with COPD and lung cancer and 62 cases of simple lung cancer patients at the same time from February 2013 to December 2017 in Affiliated Hospital of Yangzhou University.All patients were examined with multi-slice spiral CT examination and PFT lung function.We analyze the data correlation of the primary tumor location,gender,age,smoking history,smoking index,pulmonary function index and pathological types between the two groups.We measure and compare the multi-slice spiral CT quantitative measurement and lung function index differences between the case group and control group.And we also observe the correlation of multi-slice spiral CT quantitative measurement and lung function index in lung cancer with COPD patients.SPSS20.0 software is used to statistical analysis the results.Count data is compared by chi-square test,and the comparison of measurement data by t test.The lung function of three different phenotypes in patients with COPD and lung cancer is compared with F test.The difference is statistically significant if P<0.05.Results:In patients with lung cancer merger in the COPD of the group general is given priority to with male,smoking,central type lung cancer,and pathology classification squamous cell carcinoma;Where as in group of patients with simple lung cancer is women,no smoking,peripheral lung cancer,and the pathology classification is adenocarcinoma,The differences are statistically significant between the two groups,but not the age.The COPD group lung volume(V)of deep inspiration at the end is significantly higher than the control group,difference has statistical significance(P<0.05);The COPD group forced vital capacity(FVC),forced expiratory volume 1 second(FEV1)and the percentage(FEV1/FVC)are significantly higher than that of control group.The residual volume(RV),total lung volume(TLC),and the percentage(RV/TLC)are significantly lower than the control group,the differences are statistically significant(P<0.05).Conclusion:Lung cancer with COPD and simple lung cancer are independent diseases.CT manifestations and clinical features of differences can help the differential diagnosis between them,for the related basis of judging the curativePart ? Preliminary study on the feasibility of predicting postoperative pulmonary function in patients with COPD complicated with lung cancer by Quantitative CTObjective:To explore the quantitative CT that can forecast postoperative pulmonary function in patients of lung cancer,and assess the effect of surgery for patients.Materials and methods:We choose 30 cases of patients diagnosed with COPD and lung cancer from May to December 2017 in Affiliated Hospital of Yangzhou University.All patients had surgery and have preoperative and postoperative multi-slice CT examination results.The total lung volume and lung lobe volume are measured by the emphysema analysis software of 16 layers spiral CT(United Imaging U-CT510 type);the pulmonary function parameters are get using lung function detector.The main measured indicators are forced vital capacity(FVC),forced expiratory volume 1 second(FEV1),1 second forced expiratory volume accounts for the ratio of the forced vital capacity(FEV1/FVC),total lung volume(TLC),residual volume(RV).We use SPSS20.0 software to statistical analysis of the results,measurement data with x~2±s;Preoperative right and left lung and the comparison of different lung volume using one-way analysis of variance;CT lung volume index and measured pulmonary function index correlation analysis using the Pearson correlation analysis.The difference is statistically significant if P<0.05.Conclusion:It is feasible to predict the change of pulmonary function postoperative using multi-slice CT scanning,which can accurately assess the effects of resected lung tissue on postoperative lung function and predict the postoperative lung function.