Comparison Of Clinical Parameters Of Hyperlipidemia Acute Pancreatitis And Biliary Acute Pancreatitis

Objective:In recent years,with the improvement of people's quality of life and changes in dietary habits,the incidence of acute pancreatitis has increased significantly.Among them,acute pancreatitis caused by hyperlipidemia has been on the rise.Now it has become an common cause after biliary acute pancreatitis.The acute pancreatitis caused by hyperlipidemia is called hyperlipidemic acute pancreatitis(HLAP).The increasing incidence rate has attracted more and more attention from scholars.This article compares the clinical indicators of hyperlipidemia acute pancreatitis and biliary acute pancreatitis(BAP)and raises the awareness of HLAP,providing the basis for clinical diagnosis and treatment of HLAP.Methods:A retrospective analysis of 58 patients with HLAP admitted to our hospital from October 2015 to October 2017 was performed,and 63 patients with BAP treated at the same time were randomly selected as the control group.All selected patients were routinely given fasting water,gastrointestinal decompression,ECG monitoring,acid suppression,and somatostatin maintenance after entering the hospital to maintain water,electrolyte,energy,and acid-base balance.Restoration of function;preventive use of antibiotics;parenteral nutrition and early enteral nutrition support treatment,conservative treatment of symptoms do not relieve surgical indications when surgical treatment.In the course of treatment,it is necessary to dynamically monitor the changes of important organ functions such as blood glucose,inflammation indicators,coagulation function,and heart,liver,and kidney,and timely evaluate the condition and deal with each abnormal index accordingly.Record medical records of two groups of patients in detail:first,general situation:age,gender,Body mass index(BMI);second,laboratory indicators:Triglyceride(TG),cholesterol(T-CHO)within 24 hours after admission,white blood cell(WBC),blood glucose,blood calcium,alanine aminotransferase(ALT),glutamyl transpeptidase(GGT),total bilirubin(TBIL),amylase(AMY),urine amylase(UMY),lipase(LIP),C-reactive protein(CRP),procalcitonin(PCT),D-dimer levels;third,comorbidities(diabetes,fatty liver,hypertension);forth,BISAP scores,disease severity,treatment history,and prognosis.Using statistical methods,the two sets of data were compared and analyzed according to the above four aspects,and statistically significant indicators were analyzed and discussed in detail.At the same time,C-reactive protein,procalcitonin,D-dimer,and HLAP diseases were analyzed.The severity of the correlation,thus providing clinical reference for early diagnosis of HLAP,severity assessment,treatment and prognosis.Results:First,the average age of the HLAP group was(35.45±7.74)years old,and the average age of the BAP group was(52.48±8.27)years.There was a significant difference between the two groups(P<0.05).BMI in the HLAP group was(27.07±2.06)kg/m ~2 and BMI was(24.02±2.04)kg/m~2,the difference between the two groups was statistically significant(P<0.05),the proportion of males and females in the HLAP group was 2.63:1,and the male to female ratio in the BAP group was1.17:1.The difference between the two groups was statistically significant(P<0.05).Second,the comparison of laboratory parameters between the two groups was:HLAP group,blood amylase,the levels of urinary amylase,alanine aminotransferase,glutamyl transpeptidase and total bilirubin were lower than those in BAP group(P<0.05).The blood glucose,triglyceride,C-reactive protein and HLAP were lower in HLAP group.The levels of calcinogen and D-dimer were higher than those in BAP group(P<0.05).There was no significant difference in white blood cell count,serum calcium,serum lipase and cholesterol between the two groups(P>0.05).Third,Serum C-reactive protein,procalcitonin,and D-dimer levels were positively correlated with the severity of HLAP,and the difference was statistically significant(P<0.05).Forth,the incidence of fatty liver and diabetes in HLAP group was higher than that in BAP group(P<0.05).There was no significant difference in the incidence of hypertension in both groups(P>0.05).Fifth,the relapse rate of HLAP group was higher than that of BAP group,but the proportion of operation was lower than that of BAP group(P<0.05).There was no significant difference in disease cure between the two groups(P>0.05).Conclusions:The age of onset of HLAP patients is lower than that of patients with BAP,and most of them are male.Obese body types are more common.Diabetic and fatty liver are more often associated with elevated levels of triglyceride,but the levels of serum amylase and urinary amylase are not significantly increased.The levels of C-reactive protein,procalcitonin and D-dimer were significantly elevated and were positively correlated with the severity of HLAP disease.They were easy to develop to moderate and severe pancreatitis,and were easily relapsed clinically.Active hypolipidemic therapy hleps control the condition and reduce recurrence.