Prevalence Of Hyperuricemia And Its Influence Factors In Rural Area Of Henan

ObjectiveThe aim of this study was to explore the prevalence of hyperuricemia(HUA)and its influence factors in Henan rural adults,and to analysis the dose-response relationship between cardiovascular metabolic risk factors indexes and the risk for HUA.Then,the study also provides valid scientific evidence for prevention and treatment of HUA.MethodsA total of 39,259 subjects aged 18~79 years old were collected from the Henan Rural Cohort Study(Registration number: ChiCTR-OOC-15006699),using cluster sampling method.The Henan Rural Cohort Study was conducted in Yuzhou,Suiping,Tongxu,Xinxiang and Yima.The study population were excluded if they:(1)did not have information about SUA levels(n=54);(2)were diagnosed with cancer(n=332);(3)had serious renal disease(n=18).Finally,38,855subjects(15,371 men and 23,484 women)were included in the present analysis.Subjects answered the standard questionnaire and carried out the physical examination.Clinical physicians collected blood samples from each participant.Cross-sectional study was used to evaluate the prevalence of HUA and influence factors.Meta-analysis was performed to compare the findings of cross-sectional study.Restricted cubic spline was performed to assess the dose-response relationship between cardiovascular metabolic risk factors indexes and the risk for HUA.Results1.Distribution of SUA concentration: The mean serum uric acid(SUA)concentration in men(325.43±81.84?mol/L)was higher than in women(261.01±66.85?mol/L)(t = 81.414,P(27)0.05).In men,the mean SUA concentration decreased with increasing age(F = 234.100,P(27)0.05).In women,the mean SUA concentration decreased before 55 years old,and then began to increase with age(F = 73.610,P(27)0.05).The SUA concentration was higher in men than women in all age groups(P(27)0.05).2.Prevalence of HUA: The overall prevalence of HUA was 10.23% for subjects,12.80% for men and 8.56% for women.Age-standardized prevalence was performed by the direct method using the data on the population distribution in China in 2010.The corresponding age-standardized prevalence was 12.60%,20.24% for men and 8.25% for women.In men,the prevalence of HUA decreases with increasing age(Z = 429.325,P(27)0.05).In women,the prevalence of HUA decreased before 45 years old,and then began to increase with age(Z = 58.846,P(27)0.05).For meta-analysis,the overall prevalence of HUA in Chinese rural adults was 9.62%,which was slightly lower than the cross-sectional study.The pooled prevalence of HUA was 13.4%(22.9% in men and 6.9% in women)in Coastal areas and 7.8%(11.6% in men and 6.6% in women)in Inland areas.3.Risk factors of HUA: In men subjects,drinking,more vegetable and fruit intake,high fat diet,overweight,obesity,hypertension,hypercholesterolemia,low high density lipoprotein cholesterol,hypertriglyceridemia were all significantly associated with an increased risk of HUA,while high physical activity and diabetes were negatively associated with HUA.In women subjects,widowed(single/divorced/separation),more vegetable and fruit intake,overweight,obesity,hypertension,hypercholesterolemia,low high density lipoprotein cholesterol cholesterol,hypertriglyceridemia were significantly positively associated with HUA,whereas average monthly individual income(500~1000 RMB)were associated with a lower risk of HUA.4.Dose-response relationship between cardiovascular metabolic risk factors and HUA: With the continuous of blood pressure,total cholesterol,low density lipoprotein cholesterol and triglyceride,the risk of HUA gradually increases(P(27)0.05);While,the risk of HUA showd a decrease trend with increasing fasting plasma glucose and high density lipoprotein cholesterol levels(P(27)0.05).5.The relationship between cardiovascular metabolic risk factors clustering and HUA: Compared with subjects that having no metabolic risk factor,the OR(95%CI)for that having 1,2,3 and 4 factors to develop HUA in men were 1.749(1.538-1.992),3.138(2.735-3.601),3.771(3.168-4.489)and 2.479(1.659-3.704);the corresponding value in women were 2.233(1.955-2.550),3.698(3.216-4.253),5.322(4.501-6.292)and 6.440(4.743-8.745).Conclusions1.The prevalence of HUA was high in Henan rural adults,and the prevalence was greater in men than in women.In men,the prevalence of HUA decreased with increasing age.In women,the prevalence of HUA decreased before 45 years old,and then began to increase with age.2.The influence factors in men and in women were different.Therefore,targeted interventions should be carried out in different populations in order to prevent and control HUA.3.Dose-response relationship was found between cardiovascular metabolic risk factors indicators(blood pressure,fasting plasma glucose,total cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol and triglyceride)and HUA...