The Clinic Study On Cardiac Function Improvement Of Patient Suffer From Acute Myocardial Infarction Using New Tongguan Particles

ObjectiveThis study follows the contemporary secondary prevention of acute myocardial infarction treatment guideline,then formulates Chinese medicine intervention strategies,and evaluates cardiac function and safety after acute myocardial infarction which treated by new Tongguan particle through a prospective randomized study.MethodsThe study is prospective,randomized,double-blind study,acorrd the inclusion criteria,we have selected 60 patients of myocardial infarction patients in our hospital by PCI and randomly divided into treatment group(n = 30)and control group(n = 30).The treatment group took a new Tongguan particles besides routine western medicine,then the control group was given a placebo in the same manufacturers besides the routine western medicine.The treatment lasted for 3 months,gathering Qi and Blood symptoms score of clinical symptoms in patients,NYHA functional class,walking distance and Minnesota quality of life score after 6-minute walk test,and echocardiography data related indicators include ejection fraction(EF),left ventricular end diastolic diameter(LVEDD),left ventricular end-systolic inner diameter(LVESD),cardiac output,stroke volume(SV),each distraction output(CO),heart valve cases,then BNP,liver and kidney function and other safety indicators,MECE event,and readmission rates,adverse reactions and other indicators.Establish a database use SPSS17.0 software.Statistical methods are chi-square test and T-test,and the non-normal distribution of data using rank sum test.ResultsThe study included 60 cases,52 cases were completed in three months,25 cases in the experimental group and 25 cases in the control group respectively.After 3 months of treatment,three indicators of NYHA class of two groups,blood qi deficiency symptoms scale scores,Minnesota score quality of life scores,the treatment group have improved more significant compared with the control group(P<0.05).6-minute walk test distance of the two groups of patients were improved after treatment,but no significant difference between two groups(P=0.449 P>0.05),while the added value of 6-minute walk was statistically significant(P=0.009 P<0.05),compared with the control group,the treatment group increased distance much more.Echocardiography results showed that after 3 months of treatment,cardiac ultrasound treatment group include EF,LVEDD,LVESD,CO,SV have no difference compared with the control(P>0.05),LVEDD and SV results were statistically significant(P<0.05).Plasma BNP levels between the two groups after three months' treatment were lower than before,the treatment group were statiistically significant before and after treatment(P=0 P<0.05),while control group were not statiistically significant before and after treatment(P=0.17P>0.05).Safety indicators in both groups was not statistically significant(P>0.05)after treatment.The control group during the follow-up a total of three patients hospitalized again due to cardiovascular disease,no treatment group,there are significant differences(P<0.05).conclusionBased on the conventional Western medicine,the new Tongguan particles can improve reperfusion and enhance the patient's exercise tolerance,improve the quality of life of patients.The mechanism may be the new Tongguan particles could inhibit ventricular remodeling in acute myocardial infarction.