| Since the 21 st century,cancer has posed a great threat to human health.At present,chemotherapy,radiotherapy,surgical treatment and other methods are often used in the treatment of cancer,but the low efficacy and large side effects have become the main reasons for restricting its development.With the continuous innovation of science and technology,the emergence of nanotechnology in recent years provides more strategies for the treatment of tumors.Among them,the development of nano-photosensitizer materials and the application of optical therapy has attracted wide attention.At present,optical therapy mainly includes photothermal therapy and photodynamic therapy,at present,after the administration,the tumor site is irradiated by an external light source to produce heat or reactive oxygen species(ROS)to treat the tumor.Due to their advantages of high specificity,microregion control,noninvasiveand significant curative effect,optical therapy shows a great prospect in the treatment of cancer.At the same time,due to the high tissue penetration ability of NIR and good biocompatibility,it is the main light source for light therapy.Therefore,semiconductor nanomaterials with high NIR absorption capacity were synthesized in this paper,which combine photothermal and photodynamic,and study the mechanism of the materials.the magnetic or high X-ray absorption capacity of the nanomaterials is constructed,and the nuclear magnetic,CT or thermal imaging analysis is combined to establish a collaborative integration of multiple treatment methods under imaging monitoring.The specific research contentsare as follows:(1)In this chapter,we synthesized Sb2Se3 nanorods(100-200 nm in length and 50 nm in width).Sb2Se3 nanorods have narrow band gap(1.1 e V).Under the action of 808 nm,the materials show excellent photothermal properties(the photothermal conversion rate is 45.2 %)and the ability of active oxygen generation.Self-made sensitive-Se-Sesilane coupling agent was modified on the surface of the pore,which could not only prevent the leakage of Dox in the pore,but also consume excessive GSH in the tumor cells,break the balance of redox in the tumor cells,promote the increase of active oxygen concentration,and increase the effect of photodynamic therapy.Combined withthe cell test of the system and in vivo experiment of mice,the results showed that the prepared Sb2Se3@m Si O2-Se-Se hollow nanorods could cooperate with photothermal therapy/photodynamic therapy/chemotherapy under the monitoring of CT imaging.(2)In this chapter,Ni S/Cu S nanoparticles(30-80 nm)were prepared as the main body,and Ni S/Cu S nanoparticles were synthesized by Cu+ doping to improve the near-infrared absorption ability of the material.At the same time,a layer of hyaluronic acid was modified on the surface of nanoparticles,which can specifically recognize the CD44 protein on the surface of tumor cells.Gd3+ was successfully loaded on the surface of nanomaterials by chelation with hydroxyl groups on the surface of hyaluronic acid,which made the materials have good NMR imaging ability.Combined with systematic cell test and mouse in vivo experiment,the prepared NC10@HA-Gd nanomaterial has good tumor targeting,dual-mode imaging(Thermal Imaging and Magnetic Resonance Imaging)under the monitoring of composite therapy(photothermal therapy and photodynamic therapy).(3)In this chapter,we first synthesized tungsten oxide precursor,and then formed WN70 nanoparticles by high temperature reaction.In the synthesis process,urea was doped to realize the encapsulation of amorphous carbon layer.By adjusting the ratio of tungsten oxide precursor and urea,we get WN nanoparticles doped with different proportions of amorphous carbon.As a high-Z element,W element can be used in CT imaging.WN@C shows dual-mode imaging of photothermal imaging and CT imaging.Through cell experiments and mouse experiments,we can see that WN@C has obvious anti-tumor properties excited by NIR under the synergistic effect of photothermal therapy and photodynamic therapy. |
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