A New Method For The Synthesis Of Dihydroisoquinolin-1-one And Quinolin-2-one Derivatives

As an important parent structure of natural products and synthetic biologically active molecules,isoquinolinones are a class of benzo six-membered heterocyclic compounds with strong drug activity,and are widely used for inhibitors,agonists,and antagonists.Compounds containing quinolin-2-one fragments also have high bioactivity and a very wide range of applications in the fields of life sciences,organic synthesis,materials science,etc.In his paper,Using organic acid substituted with o-sulfur salts as raw materials,2,3,3-trisubstituted-3,4-dihydroisoquinolinone compounds and 1,3,4-trisubstituted quinolin-2-one compounds were synthesized by Ugi multi-component reaction/nucleophilic substitution reaction.the specific content is as follows:1.The research progress on the biological activities and Synthetic methods of 3,4-dihydroisoquinolinone compounds and quinolin-2-one compounds,and the latest research progress of Ugi multi-component reaction and the reactions involving sulfur salts were reviewed.2.2,3,3-Trisubstituted 3,4-dihydroisoquinolinone compounds(?-6)were obtained under the action of triethylamine by cyclization of Ugi-4CR products,which were prepared via reactions of ?-sulfur salt substituted benzoic acids,2-oxo-2-phenylacetaldehydes,amines,and isonitriles.The specific steps are as follows:(?)3.1,3,4,-Trisubstituted quinolin-2-ones(?-6)were obtained under the action of DBU by cyclization of Ugi-4CR products,which were prepared via reactions of ?-sulfur salt substituted benzoic acids,o-aminoaryl ketones,aldehydes and isonitriles.The specific steps are as follows:(?)...