A Methodology Study Of Heteroc Ycles Synthesis Based On Rhodium Catalysis

Heterocycles are crucial structural motifs that are ubiquitously present in biologically active natural products,pharmaceutically important compounds and functional materials.They are widely used in medicine,pesticides,functional materials and other fields due to their unique properties.Consequently,the development of simple and efficient protocols to construct heterocycles has been a general topic of particular interest.N-sulfonyl-1,2,3-triazoles compounds have been used as a novel nitrogen-containing metal carbene precursor to undergo various useful transformations such as cyclopropanization,X-H insertion,1,2-Alkyl migration,[2,3]-σ rearrangement,and other novel reactions based on the intrinsic properties of metal carbene have opened up new avenues for the rapid construction of complex and diverse heterocyclic compounds.Under the guidance of green chemistry and sustainable chemistry,based on the principles of atomic economy,high functional group tolerance,minimal protection group participation and environmental friendliness.This project designed and developed a synthetic route using N-sulfonyl-1,2,3-triazole derivatives as substrates and Rh2(oct)4 to catalyze the intramolecular cycloaddition reaction,and a series of novel hete-rocyclic compounds are obtained.When studying the yield,substrate range and tolerance of the reaction,it was found that the reaction has good yield and tolerance regardless of the electronic properties of the substituent;however,when the position of the substituent is different The yield of the reaction is significantly affected.The novel heterocyclic compounds synthesized in this subject contain two kinds of skeleton structures,namely xanthene and strontium,which have great potential application value in medicine and functional materials.