Study On Reaction Based On Unsaturated Imine And Design Synthesis Of Dihydrobenzofuran

In this thesis,Study on reaction based on unsaturated imine and design synthesis of dihydrobenzofuran,the main contents of thesis are as follows:Chapter one:Seven-membered heterocyclic compounds are widely present in natural products and antificial drugs.Nitrogen-containing heterocyclic compounds are a very important class of seven-membered heterocyclic compounds,and there are few studies on triaza compounds,so we report under mild conditions,[4+3]annulation of aza-ortho-quinone methides with azomethine imines to from 1,2,4-triaza.In addition the cyclization reaction of the aza-Michael/amination sequence is an effective method for synthesizing high-yield biological heterocyclic compounds.Chapter two:Dihydrochalcone(DHCs)compounds are a type of flavonoids.It is one of the most important and valuable functional groups in organic and bioorganic molecules,and can be found in various natural and artificial bioactive molecules.In the second chapter,we reported the in-situ reaction of aza-o-quinodimethanes(aza-o-QMs)with the substrate ketone oer eater enolate in the presence of TMAF by 1.4-elimination.The strategy is to synthesize a variety of substituted 2-(p-toluenesulfonyl)dihydrochalcone under one-pot method under mild conditions.In addition,various 2-(p-toluenesulfonamido)dihydrochalcone can be easily converted into various heterocyclic compounds.Chapter three:2,3-dihydrobenzofurans are key building blocks in many biologically active natural products and synthetic bioactive molecules.A simple,efficient,and general method has been developed for the simple diastereoselective synthesis of 2,3,disubstituted dihydrobenzofurans through reactions of 2-hydroxyaryl-?,?-unsaturated ketones with sulfur ylides with high chemo-and stereoselectivity.