| Heterocyclic compound is an extremely important class of compounds,and one of the most common,diverse and abundant compounds in nature.Heterocyclic compounds are not only widely found in natural products and drug molecules,but also used in the fields of polymer chemistry and material chemistry.In addition,heterocyclic compounds can also be used as protective groups,organic catalysts,intermediates,etc.in organic synthesis reactions.Therefore,it is of great significance to adhere to the concept of environmentally benign chemistry,develop the environmentally friendly synthesis method of heterocyclic compounds,and promote the research of environmentally friendly organic synthesis methods,which has also received considerable attention from chemists.Based on the study of cyclization reaction between sulfonium salt with simple and easily obtained substrate,this paper quickly and efficiently constructs heterocyclic compounds such as oxepine,3-(methylthio)-4 quinolinone,thiazoline,etc.by simple synthesis methods under mild conditions.The main research contents are as follows:Firstly,we developed one pot of sulfonium salt and benzaldehyde derived from the reaction of crotonate.The multicomponent [4+3] cycloaddition of 1,3-indandione occurred.Indeno [1,2-b] oxepine compounds with various structures can be rapidly synthesized by this strategy.The substrate in this method has the advantages of good universality,high yield,simple synthesis procedure,which conforms to the concept of environmentally benign chemistry.Secondly,the synthesis of 3-(methylthio)-4 quinolinone derivatives was successfully developed.We used propargyl sulfonium salt and isatoic acid anhydride as ingredients,DMAP as alkali catalyst and obtained a series of target products with high yield by [4+2] cycloaddition.Finally,the [3+2] cyclization reaction of sulfonium salt derived from crotonates and β-ketone thioamide was designed.A series of compounds containing thiazoline framework were successfully synthesized.At the same time,when using 1-methyl-2-oxy-N-arylindolino-3-thioamide as raw material to react with sulfonium salt,the molecular framework of spiro [indolino-3,3’-thiophene] was accidentally constructed. |
