Fabrication And Properties Of Electrospun Nano-silver EVOH Oriented Fibres

Burm is a common injury.The most important thing dealing with the wound is to avoid infection.Wrapping the wound with gauze after cleaning and covering antibiotics is usually the traditional therapies.Mowever,when the drug is absorbed,new drugs and gauze needs to replenishing in time,which cause the patient’s secondary pain.Meanwhile,it makes the wound frequently exposed to the air and increases the probability of contact with bacteria.Besides,the human body will produce resistance to them by using antibiotics for long time.Therefore,the traditional treatment methods can not satisfy people’s requirements for rapid and painless treatment.In this study,nano-fibre mats with sustained anti-bacterial effect for skin wound dressings fabricated by electrospinning were introduced.The main contents are as follows:Firstly,the process of preparing ethylene-vinyl alcohol polymer(EVOH)nanofibres with different silver concentration(0,0.02g/ml,0.05g/ml,0.08g/ml)by electrospinning was introduced.The selection of parameters in electrospinning process,such as voltage,distance from needle to collector,temperature,etc.,was improved by fabrication of different nanofibre mats.Moreover,the microstructures of the nanofibre mats were obtained with Scanning Electron Microscopy(SEM)and Energy Dispersive X-ray Spectrometer(EDX).Besides,the effects of various parameters on the electrospinning process,morphology and diameter of the obtained fibers were investigated.Secondly,tensile properties of nanofibre mats with different EVOH mass fraction and silver concentration were tested to obtain the influence regulations of EVOH mass fraction and silver concentration on the tensile properties.In addition,the Young’s modulus and conditional yield strength were calculated to ensure that the nanofibre mats could satisfy the mechanical requirements of storage,transportation and use.Finally,the main biological properties of nanofibre mats with 10%EVOH in different silver concentrations were studied,including the antibacterial properties(mainly for Staphylococcus aureus),biocompatibility and water vapor permeability.These properties were tested to investigate the effect of continuous antimicrobial activity,judge the permeability of the fibre mats and analyze the growth of cells on the fibre matsIn this study,by fabricating nanofibre mats with different EVOH mass fraction and silver concentration for many times,the suitable selection range of each parameter was elaborated in detail.Besides,the effects of parameters on the morphology and diameter of fibre were obtained.In addition,the mechanical and biological properties of the nanofibre mats were tested.Therefore,the nanofibre mats could be used as a new wound dressing with high efficiency,persistent antimicrobial activity,non-toxicity and biodegradable properties.