| At present,there are three kinds of tumor treatment methods:surgery,radiotherapy and chemotherapy.Whether it is chemotherapy on the basis of surgery and radiotherapy,or simply relying on chemotherapy means of anti-tumor research,it is indisputable that chemotherapy has become the most commonly used means of anti-tumor.Cytotoxic drugs are often used as anti-tumor drugs in chemotherapy.However,due to their lack of specificity,they not only have toxic effects on tumor cells,but also exhibit cytotoxicity on normal cells.The low utilization rate of drugs and relatively large toxic and side effects greatly limit the application of chemotherapy.In this study,the sulfide nano-core-shell structure with NIR as the excitation condition was prepared.Copper sulfide/iron nano-materials can absorb NIR light and convert it into heat,which can be applied to the photothermal treatment of tumor cells.Moreover,the hollow structure inside can be used as a drug carrier to support the treatment of anticancer drugs.At the same time,its absorption of light into heat can accelerate the release of drugs,to achieve the control of the release of anticancer drugs.The main research content is as follows:?1?Taking CuO as precursor and template,the hollow CuS nano-block structure was synthesized by changing reactant concentration and reaction time,and the size was about 250-300nm.Due to its rich porous structure,the shell provides space for the anticancer drug adriamycin.Hollow nanostructures have novel properties of rapidly triggering nir absorption.In addition,ROS production is also achieved by adding some entrapers.To further improve the monodispersive biocompatibility,PEG-NH2 was modified to form DOX-CuS@PEG outside the nanostructure,revealing the release performance of acid near infrared sensitivity.The efficacy of DOX-CuS@PEG combined with chemotherapy combined with PTT and PDT showed specific properties to enhance the cytotoxicity of cancer cells.?2?FeS2@Cyolk-shell nanomaterials with both photothermal and photodynamic properties were synthesized.Fe3O4@C was firstly synthesized by a simple one-step hydrothermal method,and then Fe3O4@C was acidified and etched to obtain Fe3O4@C structure with yolk-shell structure.And then we get FeS2@C by simple hydrothermal vulcanization.It has strong near infrared absorption and high photothermal conversion due to its narrow band gap?1.52 eV?and novel hollow structure.As expected,FeS2@Cyolk-shell nano-materials also revealed the generation of ROS under near-infrared irradiation,and the generation process was studied in detail by adding capture agent and ESR.It was shown that·OH and·O2-were the main active groups in the system,and the generation of ROS was determined by photoexcited electrons and dissolved O2.By evaluating the energy band of FeS2,it was found that CB potential was sufficient to oxidize water to form O2.As expected,the dissolution of oxygen was also detected to further enhance PDT and alleviate hypoxia.In addition,FeS2 can be degraded by fenton reaction of Fe ion to generate·OH and O2 to assist PDT.In order to make full use of the hollow structure,photosensitizer ICG was added into the material to further improve the effect of PTT and PDT.PEG-NH2was then loaded onto the nanomaterial to further ensure its monodispersity and biocompatibility.The synergistic effect of PTT and PDT enhanced the anticancer effect.?3?SiO2@Fe3O4@C was synthesized by a simple one-step hydrothermal method,and then the template SiO2 was removed by sodium bicarbonate to obtain hollow Fe3O4@C.The size of the synthesized hollow nanostructures is about 150-180nm.Then the product FeS2@C was obtained by mild vulcanization.Gold was functionalized by a simple mechanical stirring method.In order to improve its material monodispersity of PEG modification,FeS2@C@Au@PEG,the dissolution of oxygen can also be detected further enhance PDT and alleviate hypoxia,so using the hollow structure,the material of oxygen loading,found that the near infrared?NIR?light mediated effect of field can trigger the load in the hollow nanostructures PFC timely release oxygen,significantly improve the efficiency of PDT.The hollow structure provides a large space for the loading of photosensitizer ICG and O2.In addition,because the hollow porous nano-structure has good near infrared absorption performance,the hollow nano-material has fast near infrared trigger temperature increment and reactive oxygen generation.The synergistic effect of chemotherapy combined with PTT and PDT enhanced the specific cytotoxicity of tumor cells. |
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