Construction Of Transiton Metal Oxide Nanoarrays 3D Self-supported Electrode And Its Application In Enzyme-free Glucose Electrochemical Sensing

Accurate detection of glucose concentration is of great significance in clinical medicine,biomedicine,food industry,bioprocessing,and fuel cells.The electrochemical enzyme?GOx?glucose could detect the concentration of glucose accurately,however,the nature of enzymes makes it susceptible to environmental factors,such as temperature,pH,etc.Consequently,the design and development of enzyme-free glucose sensor has attracted more attention in past decades.Although noble metal nanomaterials showed efficiency for enzyme-free glucose sensing,they are easy to be poisoned and they are expensive.Recently,more and more transition metals have been used for enzyme-free glucose sensing because of their low-cost and abundant-reserves.However,the nature of semiconductor of these metal oxides endows it low conductivity,as well as the immobilization of these catalyst with the use of polymer binder which would block some active sites and lead to the reduced performance with inferior performance.Therefore,it is significant importance to boost the performance of glucose sensor through improving the conductivity and creating more active sites of these electrocatalysts.In this thesis,the aim is to design and develop several enzyme-free glucose senors with high performance by preparing nanoarrays array 3D self-supported electrode,fabricating hierarchical nanostructure and regulating electron structure of catalysts as folllows.1.A MnO₂ nanosheet array?MnO₂ NSA/NF?3D self supporting electrode is synthesized by hydrothermal method in situ with nickel foam as substrate,and applied to enzyme-free glucose sensing.MnO₂ NSA/NF has good performance in detecting glucose without enzyme.Its detection sensitivity is 6.45 mA/mM·cm² with detection limit of 1?M?S/N=3?.The electrode has good selectivity for detecting glucose and can be used for the detection of actual blood samples.2.Co?OH?₂ nanotube arrays?Co?OH?₂ NTAs/CC?with hierarchical structure are prepared by anion exchange method on carbon cloth.Experiments show that Co?OH?₂NTAs/CC has good catalytic performance for the oxidation of glucose.Its detection sensitivity can reach 2.77 mA/mM·cm² and the detection limit is 0.5?M?S/N=3?.Co?OH?₂ NTAs/CC has good anti-interference performance,which can be directly used for the detection of real blood samples.3.NiMoO₄ nanosheet array 3D self-supporting electrode?NiMoO₄ NSA/CC?is prepared through hydrothermal method which using carbon cloth as the substrate.The electrochemical results show that NiMoO₄ NSA/CC has high catalytic activity for the electrochemical oxidation of glucose.The detection sensitivity of NiMoO₄ NSA/CC is4.13 mA/mM·cm² and the detection limit is as low as 1?M?S/N=3?.The sensor has high selectivity and can be used to detect the content of glucose in real blood samples.