| Diabetes(Diabetes Mellitus DM)is a endocrine diseases that caused high blood sugar caused by relative or absolute lack of insulin secretion,there is not a clear conclusion about the pathogenesis of diabetes,scientific research shows that diabetes is a common effect of environmental factors and genetic factors,autoimmune factors,results.Diabetes is mainly divided into three types: type Ⅰ,type Ⅱ and gestational diabetes,and most of them are type Ⅱ diabetes.Exercise therapy,dietotherapy,and drug therapy are the main treatment methods of diabetes.With the development of modern society,the deterioration of ecological environment and accelerate the pace of life,people always stay in the mental stress,lifestyle disorders,air pollution and other adverse environments,that makes the incidence of diabetes is high,and the trend of younger in china,young people have been plagued by diabetes.At present,there is still no cure for diabetes.Because diabetic patients lose a lot of nutrition in the process of illness,so nutritional therapy is a more effective way without side effects,which has attracted more and more attention in recent years.Enteral nutrition is one of the ways of nutrition therapy,special disease specific type of intestinal for diabetes in nutrition is few at home and abroad,so the development of new model for diabetes enteral nutrition preparation will have a broad market prospect and practical significance.Spirulina nutritious is a kind of high-quality enteral nutrition preparation of raw materials,which are rich in protein,fatty acids,polysaccharides,vitamins,minerals and a variety of bioactive substances,many studies show that Spirulina has good hypoglycemic function,so the development for diabetes enteral nutrition can make full use of Spirulina value.So we analyze the nutritional components of the spirulina,which is a new type of conduit fluid culture.The contents of four mineral elements including iron,zinc,manganese and selenium were determined by atomic flame method.The contents of 17 common amino acids in them were determined by gas chromatography,and the fatty acid composition was determined by acid hydrolysis.By comparing with the traditional culture methods and other algae,the nutritional value of the new pipeline aquaculture method was evaluated and its nutritional advantages were analyzed.The results show that the protein content of Spirulina production of new pipeline fluid breeding way is 65.2 g/100 g,higher than the traditional way of breeding Spirulina protein content 60.4 g/100g;ash content was 6.15 g/100 g,lower than the traditional way of Spirulina farming;amino acid analysis and comparison of Spirulina and amino acid in Chlorella,spirulina obtained contains 18 kinds of amino acids and essential amino acids in total the content of 24.53%,accounting for 40.26% of the total amino acids.Compared with Chlorella,slightly higher than the total amino content in Spirulina,Chlorella,essential amino acid content of Chlorella and close to some important amino acid was significantly higher than that of chlorella.The iron content of Spirulina(118 mg/100g)rich,Mn(24 mg/100g)compared with other algae is relatively high;the crude fat content of new farming methods for 5.15 g/100 g,4.93 g/100 g higher than that of traditional farming methods,mainly unsaturated fatty acid,gamma linolenic acid content was 264.7 mg/100 g,which in other natural plant food is rare.The protein content of Spirulina as a good source of protein in pipeline of new farming methods of high fat,low ash content,amino acids,essential amino acids and contains a variety of mineral elements,heavy metal content is low,can be used as a high quality protein source in the application of enteral nutrition preparation.According to the special pathophysiological changes,metabolic characteristics and energy requirements of diabetic patients,Spirulina is used as the source of high quality protein,and a specific enteral nutrition preparation is prepared.This preparation contains hectogram energy 1723.97 KJ energy sources are respectively: 66.56% carbohydrates,14.16% protein and 19.28% fat.The main energy supply substances are protein 19.55 g,fat 6.6 g,carbohydrate 67.50 g,respectively.Besides,vitamins,minerals,inositol,choline,taurine and folic acid are added to design a formula for enteral nutrition which is not only reasonable in proportion but also satisfies the nutritional needs of diabetic patients.The digestibility and characteristics of Spirulina and spirulina enteral nutrition preparations were analyzed in vitro,and the digestion rate and digestion degree of Spirulina and spirulina enteral nutrition preparations were analyzed.The in vitro gastrointestinal digestion simulation experiments,carried out three kinds of Spirulina and enteral nutrition preparation results showed that Spirulina platensis and enteral nutrition preparation of A,B and C simulated gastrointestinal digestion system is the most essential amino acids were 207.6 mg/100 m L,66.8 mg/100 m L,62.4 mg/100 m L and 64.2 mg/ 100 m L,accounted for 84% of the total essential amino acids in the initial sample,94%,89% and 92%.Nitrogen release slowly in Spirulina platensis enteralnutrient A,B,C,spirulina enteralnutrient C and slow in A,B,gastrointestinal digestion of Spirulina Spirulina and enteral nutrition preparation of A,B,C of the nitrogen release rate range is 88.09% + 0.98%-92.24% + 1.87%,the difference between the three kinds of nutrient release preparation of nitrogen Spirulina enteral amount is not significant,and the spirulina Spirulina enteral nutrition preparations have significant difference.Spirulina enteral nutrition preparation is rational in composition and stable in vitro digestion rate.Spirulina and spirulina enteral nutrition preparation are excellent raw materials and preparations for nutritional support.Preparation of type 2 diabetic mice model with alloxan four,explore the impact of the metabolic characteristics of Spirulina enteral nutrition on diabetic mice,50 mice were divided into successful model into 5 groups,10 rats in each group: experimental group,experimental group A(TGA)B(TGB),experimental group C(TGC),positive control group(PCG),control group(BG)and control group(CG),another 10 mice as control group.Through the mouse appearance,body weight,fasting blood glucose,serum insulin and GIP-1(glucagon like peptide-1(GIP)and Glucose dependent insulinotropic polypeptide)and other indicators show that the positive control group(PCG),experimental group A(TGA),experimental group B(TGB),experimental group(C TGC)can improve the diabetic mice to a certain extent symptoms.The positive control group(PCG)had the best effect,the experimental group A(TGA),the experimental group B(TGB),the experimental group C(TGC),and the difference between the three groups was not obvious. |
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