Asymmetric [3+2] Cycloaddition Reactions Of Diazophosphonates With Benzoyl Dicarboxylates

Heterocyclic compounds are ubiquitous in nature and in various organisms.How to efficiently synthesize such compounds with heterocyclic structure has always been the focus of research by scientists.Among these heterocyclic compounds,scientists have discovered that compounds with the structural characteristics of phosphonopyrazolines are a relatively important and widely existing heterocyclic compound,so how to efficiently synthesize such a compound having a phosphonopyrazoline structure has a very important SignificanceIn this paper,the asymmetric [3+2] cycloaddition reactions of diethyl benzalmalonate and ?-diazophosphonate were designed and synthesized to efficiently synthesize a class of pyrazolyl ring structures.By designing a series of catalysts we expect to achieve the desired catalytic effect.Through the previous screening of the catalyst,we found that the quaternary ammonium salt phase transfer catalysts derived from cinchonaine can achieve a better enantioselectivity and higher yield for this reaction.In the later stages,the catalyst will still be further optimized and it is expected that better results will be obtained.