Study On The Production Process And Quality Control Of Yin Kou Cold Particles

Yin Kou cold particles is a prescription composed of 8 herbs.The extract process,Laboratory Technology of Yin Kou cold particles is studied,and according to the results of the research and optimization of several key technology in the production process.At the same time,the quality standard is studied.Yin Kou cold particles volatile oil extraction,water extraction process were investigated.The record of the relevant process and results of the test data in the lab and pilot test results were analyzed,the volatile oil extraction equipment to carry out the transformation and the development of operating points in the pilot process,the improved extraction of volatile oil rate of laboratory test rate of 90%;and according to the actual production condition of process parameters by orthogonal experimental design to optimize the water extraction.It was concluded that the optimumtechnological condition of water extraction process was 11 times of water heating to 60 degrees C,1 hours after the extraction,process improvement,the effective component of the transfer rate of chlorogenic acid increased by 19.59%.The boiling granulating process of were investigated.Boiling granulation adopts two different ways.The accessories for the bottom material to extract as adhesive materials,granulation;second to extract powder as material,starch as adhesive.Through the analysis of the experimental results,the two methods can get qualified particles which meet the requirements of the granules.But the former can save equipment investment,and shorten the production cycle.The choice of materials for the bottom material to extract the adhesive for fluidized bed granulation.In the three batch of pilot study,the results showed that the extraction rate of volatile oil,the transfer rate of chlorogenic acid,the quality of granules and the yield of granules were all able to reproduce,which indicated that the process was stable and feasible.Study on the quality standard of silver cold particles showed that honeysuckle,Scutellaria,cardamom cardamom TLC method is simple and feasible,with strong specificity.Make the content limit content of chlorogenic acid in Yin Kou cold particles : each bag of chlorogenic acid(4g)containing not less than 32 mg.The three batch of samples in accordance with the general provisions of the Pharmacopoeia of theexamination,the results are in line with the provisions of.