Effect Of Probiotics Lactobacillus Casei Zhang On Gut Microbiota Of Young People Living In Hainan

Many studies have confirmed that gut microbiota is closely related to human health.Different dietary structures and geographical environments will cause different effects on gut microbiota.Probiotics can improve health and prevent disease by regulating the gut microbiota.And probiotics have different effects on the gut microbiota of different populations.Hainan Province has a special geographical location.And Hainan's environment,climate,and diet have certain characteristics.These factors may make the young population in Hainan have unique gut microbiota.However,there are few related studies on the gut microbiota of the young population living in Hainan.It is unknown how L.casei Zhang will affect the gut microbiota of Hainan young population.Twenty-nine healthy young volunteers from Hainan were selected as the research objects.Volunteers were supplemented with 1×1010 CFU L.casei Zhang powders per day,lasting 14 days.Fecal samples were collected on 0 day,7 day,14 day and 28 day(Stop taking probiotic L.casei Zhang for 14 days).Microbial diversity of gut and the effects of L.casei Zhang on the fecal microbiota were analyzed by PacBio SMRT.The results are as follows:(1)The gut microbiota of volunteers mainly composed of Firmicutes,Bacteroides,Proteobacteria,Actinomycetes and Tenericutes at the phylum level.At the genus level,gut microbiota mainly consisted of Bacteroides,Bacteroides,Faecalibacterium,Eubacterium,Clostridium,Prevotella,etc.At the species level,gut microbiota mainly composed of Faecalibacterium prausnitzii,Eubacterium rectale,Prevotella copri,Bacteroides plebeius,Bacteroides vulgatus,etc.And the volunteers' gut microbiota is closely related to the local diet.(2)Continuous consumption of probiotics L.casei Zhang for 2 weeks had no significant effect on the gut microbiota diversity and structure,while the the abundance of some bacteria changed significantly.After taking L.casei Zhang for 14 day,the relative content of beneficial bacteria increased significantly,such as Oscillospira and Parabacteroides.And the relative content of harmful bacteria decreased significantly,such as Aeromonas,Enhydrobacter and Fusicatenibacter.(3)The probiotic L.casei Zhang can survive in the intestines of volunteers for more than 2 weeks.In addition,the probiotic L.casei Zhang may ignificantly increase the intestinal flora's inorganic ion transport and metabolism,promoting the absorption of nutrients by the human intestinal flora.