Changes And Clinical Analysis Of Electrocardiogram, Myocardial Markers And MiRNA223 In Different Subtypes Of Cerebral Infarction

Object:This study is based on OCSP classification,objective to study the electrocardiogram,myocardial markers in different subtypes of cerebral infarction,determination the clinical significance of early myocardial damage,and explore more sensitive biomarkers.Specific purpose:(1)Analyzing the relationship of OCSP,ECG,myocardial markers,NIHSS and mRS,which to explore the prognosis of different subtype patients.(2)Analyze the relationship between OCSP and miR-223 in patients,which provide new ideas for early prevention,diagnosis and prognosis.Methods: Continuous collected 159 cases of cerebral infarction,which admitted to the Department of Neurology of Hongqi Hospital Affiliated to Mudanjiang Medical University from September 2015 to September 2016.First of all,we should collect the general data(gender,age,past history),Vital signs(body temperature,heart rate,blood pressure).On the first day of admission,we should collect OCSP,NIHSS and mRS(NIHSS and mRS were divided into admission and discharge)and ECG.The next morning venous blood was collected for determination of myocardial markers,biochemical,blood routine and blood coagulation,immediately send laboratory detection.27 cases of cerebral infarction and 10 healthy volunteers were detected by mi R-223,5ml of venous blood was collected in a EDTA containing anticoagulant tubeat the same time with others,miR-223 was detected by Real-Time PCR.All the subjects entered the computer database.Results:(1)The total accuracy of OCSP is 83.0%,TACI is 81.0%,PACI is 89.6%,POCI is 77.1% and LACI is 82.4%.(2)The abnormal rate of ECG is 63.52%.The total abnormal rate of ECG in TACI was the highest,followed by PACI,POCI and LACI.There was significant difference between the four groups in ECG abnormal rate(P<0.01)(3)The abnormal rate of myocardial enzyme spectrum is 27.7%.HBDH and CK increased significantly,CK-MB and cTnI were not significantly elevated.(4)TACI has the highest NIHSS score(7.69±4.40),the most nerve defect,the highest mRS score(3.29 + 1.33),and the worst prognosis;followed by PACI and POCI,LACI has the lowest NIHSS score(0.85±0.82),the lightest nerve defect,the lowest mRS score(1.06±0.55),and the best prognosis.(5)TACI was significantly higher than LACI(P<0.05).Conclusions:(1)The accuracy of OCSP classification is high,OCSP classification and imaging results have good consistency.(2)TACI is prone to abnormal ECG,ECG monitoring should be strengthened,followed by PACI,POCI and LACI.(3)TACI was prone to CK,followed by POCI,PACI and LACI.(4)For patients with cerebral infarction,the application of OCSP classification,NIHSS score,mRS score,can make a comprehensive evaluation of patients,useful to guiding treatment and evaluating prognosis(5)The expression level of mi R-223 in TACI group was increased,which may be related to the severity of disease.