| Objective:Based on the three priority principles proposed by Professor Jia Chunhua for the treatment of complex diseases,to explore the principle of syndrome differentiation and treatment of complex diseases treated by Zhang Zhongjing,clarify the basic connotation,classification of syndromes,rule prescriptions and significance of complex diseases,in order to facilitate the mastery of Zhong Jing’s treatment of complex diseases and guide the traditional Chinese medicine clinical trials.At the same time,observe and analyze the changes of various indicators in the syndrome of intermingled chronic illness and new disease experiment,and discuss the principle of Zhang Zhong-jing’s treatment of complex diseases from the perspective of modern medicine.Methods:In terms of theoretical research,the study started with the articles and prescriptions on Treatise on Febrile and Miscellaneous Diseases.Through the original reading and literature search,the content of complex diseases in Treatise on Febrile and Miscellaneous Diseases was analyzed and classified.In summary,it reveals the rules of dialectical treatment and treatment principles.In the experimental study,the experiment selected diabetic rats as a“chronic illness"model,and lung infection as a "new disease" model.On the basis of diabetic rats,lung infection was superimposed to replicate the“new disease" model.Jinkui Shenqi Pills for the treatment of chronic illness--diabetes,and Yin Qiaosan for the treatment of new disease--lung infection,48 SD male rats were randomly divided into 4 groups:blank group,"chronic illness--new disease" model group,the first-chronic illness group and the first-new disease group,by measuring the content of fasting blood glucose,insulin resistance index,blood lipids and oxygen free radicals malondialdehyde(MDA),superoxide dismutase(SOD),lung index in rat,to study the pharmacodynamic effects of each drug group under the intervention of drugs and compare the differences.Results:Theoretical research,through the collation of "complicated diseases" in Treatise on Febrile and Miscellaneous Diseases,analyzes the following results:1,Defined the connotation of complex diseases and correctly identified complex diseases,it is known that complex diseases refer to multiple meridian,multiple organs,as well as the exterior-interior concurrent disease,confusion of deficiency and excess,confusion of yin and yang,simultaneous occurrence of cold and heat etc.,and Correct identification of complex diseases should be " comprehensive analysis of pulse and symptoms".2.Complex diseases in Treatise on Febrile and Miscellaneous Diseases mainly include the exterior-interior concurrent disease,syndrome of intermingled chronic illness and new disease,and syndrome of intermingled heat and cold,arranging and summarizing the relevant provisions and expounding the interpretation of each article.On the basis of Professor Jia Chunhua’s three priorities:"taking emergency as first," "taking exterior as the first," and "taking the ease as the first," summed up Zhongjing’s rule of treating complicated diseases.The " taking emergency as first " principle is mainly manifested in the interior disease of the body is urgent,concurrent disease of three yang channels,shaoyin disease with indications for three drastic catharsis;The principle of " taking exterior as the first" is mainly manifested in the cause of the disease tends to the exterior of the body or the interior disease is not urgent;the principle of " taking emergency as first " is mainly manifested in the syndrome of intermingled chronic illness and new disease to treat the new disease as the first principle.3.Through the study of the laws of three complex diseases,we found that Zhong Jing’s treatment principles for complex diseases can be classified into three priority principles:"taking emergency as first","taking exterior as the first",and "taking advantage of ease as the first".Clinical applications of these three priority principles are also divided into successive stages.They should follow the order of "taking emergency as first","taking exterior as the first",and "taking advantage of ease as the first".In this way,we can correctly apply the three priority principles and bring into play the advantages of clinical treatment.In the experimental study,compared with the blank group,the fasting blood glucose,blood lipids,MDA and lung index of the model group were significantly higher(P<0.05),and the insulin sensitivity index and SOD were significantly lower,and the difference was statistically significant(P<0.05).Compared with the model group,the fasting blood glucose,blood lipids,MDA,and lung index were significantly decreased in the first-new disease group and the first-chronic illness group(P<0.05),and the insulin sensitivity index and SOD were significantly increased.The difference was statistically significant(P<0.05);fasting blood glucose,blood lipids,MDA,and lung index were significantly lower in the first-new disease group than in the first-chronic illness group(P<0.05).The insulin sensitivity index SOD increased significantly and the difference was statistically significant(P<0.05).Conclusion:In the theoretical research part,the complexity of the pathogenesis of complex diseases is complex and the clinical manifestations are diverse.The treatment should first clarify the treatment sequence.In this regard,Zhong Jing distinguishes the symptoms of interior and exterior,chronic disease,cold and heat,chronic disease and new diseases,forms three priority principles:"taking emergency as first","taking exterior as the first",and "taking advantage of ease as the first".The three priority principles are not contradictory.If a disease meets the above two or three principles at the same time,it will first be treated as "emergency",then "exterior",and finally"easily".With this sequence of treatment,the key to treatment can be found in complex diseases.Zhong Jing’s thought on the management of complex diseases is an important part of Zhong Jing’s academic thought.He has divided clinical treatment one after another,heeded the treatment ideas,and has an important guiding role.In the experimental research part,through experimental verification,in the treatment of re-inductive lung infection based on diabetes,the first treatment of lung infection is more conducive to the improvement of diabetes and pulmonary infection than the first treatment of diabetes,and provides the principle of treatment for"combination of chronic illness and new disease".Based on the experimental basis,Zhang Zhongjing’s treatment principles for complex diseases are interpreted from the current medical perspective. |
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