The Pathological Mechanism Of Rickets Based On Tissue Hemorrhage And Chronic Inflammatory Response

Objective and significance:The theory of Sliding Anal Cushions has been widely accepted.The present study reveals that the Anal Cushions of the patients with hemorrhoids show typical pathological changes,presenting irregular venous dilatation,thrombosis,collagen fibers and elastic fibers,such as degeneration and loosening of the tissue,and subcutaneous myondenaturation,but this theory and other hypotheses are all The pathological mechanism of hemorrhoids could not be fully explained.The purpose of this study is to make clear the common pathological changes of hemorrhoids by statistical analysis of the clinical data and pathological diagnosis of hemorrhoids,and to explore the nature and pathological mechanism of hemorrhoids.Methods:all the cases were included in the hemorrhoids patients who were hospitalized in the anorectal Department of Dongzhimen hospital,Dongzhimen Hospital of Beijing University of Chinese Medicine from January 2014 to August 2016,and all the pathological diagnosis results were extracted in the pathology department during this period.All patients with hemorrhoids with pathological results were extracted from the hospital records system.The clinical information included sex,age,clinical symptoms,signs,basic diseases,and surgical data.According to the degree of hemorrhoids,hemorrhoids were divided into I-IV degrees.According to the degree of blood,the blood was classified into four categories:no blood,hand paper,blood,blood and ejection.We consulted all the pathological diagnosis data of hemorrhoids and mucous membrane in hemorrhoids patients.The pathological results were refined and classified into Access2000 database.The clinical data and pathological data were analyzed statistically.Results:a total of 417 patients with hemorrhoids were included in this study,including 184 men(44.1%),233 women(55.9%),age 50.63 14.71,and the course of illness 78.72 + 99.87 months.In clinical symptoms,there were swelling and disappearance,anus pain,difficulty in defecation,anal Zhou Saoyang,anal swelling,discomfort,anal distention,anal discomfort,and other symptoms,including hemorrhoids I,II,III and IV,respectively,34.5%,29.7%,10.1%and 18.7%,which were found frequently in pathological results.The pathological description was:chronic inflammation,acute inflammation,acute and chronic inflammation,lymphocytic hyperplasia,lymphocytic infiltration,chronic suppurative inflammation,lymphatic follicle formation,fibrous tissue hyperplasia,anal papillary change,inflammatory granulation tissue,adenomatous hyperplasia,squamous epithelium hyperplasia,squamous epithelium pseudo epithelioma like hyperplasia,fatty group Tumor like hyperplasia,smooth muscle hyperplasia,glandular expansion,hyperplasia of gland,hyperplasia of adipose tissue,epithelia,local adenomatous polyps,adenomatoid changes of local glands,accumulation of foam like cells in the lamina propria,squamous epithelium and columnar epithelium,black disease,thrombus,thrombosis,thrombus,and thrombus It is characterized by degeneration,erosion,adenomatous hyperplasia,ulceration,edema,Pine,calcification,striated muscle and local epidermal rupture.In this study,50.8%of chronic hemorrhoids were characterized by chronic inflammatory reaction,while 79.9%of hemorrhoids were found bleeding.The chronic inflammatory cell infiltration and hyperplastic tissue were combined with chronic inflammatory expression group with no chronic inflammatory symptoms as the control group.The statistical analysis showed that there were no significant differences between the two groups in general situation,basic disease,clinical diagnosis and treatment,hemorrhoid disease classification and blood pressure classification.The analysis of the relationship between chronic inflammation and tissue hemorrhage showed that there were significant statistical differences between the chronic inflammation group and the non chronic inflammation group.P=0.001<0.05 showed a positive correlation between haemorrhoid hemorrhage and chronic inflammatory manifestations of hemorrhoids.Conclusion and significance:a considerable number of hemorrhoids are chronic inflammatory reactions,and the pathologically reported patients with chronic inflammatory reactions do not exhibit special symptoms.The chronic inflammatory reaction is a basic pathological process in the development of hemorrhoids,so the chronic inflammatory reaction may be the formation of hemorrhoids.An important factor in the exhibition.While hemorrhoidal tissue injury may lead to chronic inflammation of the initiating factors.Injury chronic inflammatory reaction may be one of the pathological mechanisms of hemorrhoids.This conclusion will guide us in future treatment,and we should pay attention to anti inflammatory therapy for patients with hemorrhoids.