Study On The Distribution Characteristics Of TCM Syndromes In Patients With Chronic Obstructive Pulmonary Disease Complicated With Pulmonary Hypertension

Purpose: In this study,chronic obstructive pulmonary disease with pulmonary hypertension as a starting point,it refers to the concept of medical practice and mathematical statistics,for the medical syndromes of the relevant statistical analysis.And it tries to explore the distribution of TCM syndromes of this disease,and deepen the understanding of the disease of traditional Chinese medicine,so that TCM differentiation is more standardized and objective.For the establishment of the standard of disease providing objective basis for clinical prevention and treatment,it also can provide a reference.research method: 1.Literature research Computer retrieval's CNKI,Wanfang database,VIP and CBM collected the relevant literatures about TCM syndromes of COPD with pulmonary hypertension in recent 15 years,so it can progress the syndromes extraction and analysis.And it also can using frequency,clustering and correlation analysis to explore its characteristics and laws.2.Clinical researchIn 52 cases of COPD with pulmonary hypertension in patients with clinical filled in the questionnaire,and based on TCM four diagnostic information on the characteristics of TCM syndrome factors distribution,it can progress exploratory analysis by using variance analysis and nonparametric test.Results: 1.Results of literature researchIn this study,25 references to the standard literature are retrieved.There are 2098 cases of the total number of cases.The study can extract the 2 syndrome elements of disease location,respectively the lung(64.45%)and kidney(35.55%).There are 5 nature syndromes of the disease,in which the solid syndrome elements are 2 kinds,for stasis(38.78%)and phlegm(28.67%).There are 3 kinds of deficiency syndrome elements,respectively the deficiency of Qi(26.75%),Yang(1.29%)and Yin(4.52%).The types of syndromes can be grouped into three combinations,including the form of one syndrome(15.92%),the form of double syndromes(46.66%),and the form of three syndromes(37.42%).Double syndrome factors is the highest frequency of combination,and especially blood stasis + phlegm is the most common.In terms of the relations between emptiness and solidity of the disease,the majority combinations is mixture of emptiness and solidity,accounting for 52.76%.Clustering analysis is divided into four categories,C1: lung,kidney,yang deficiency;C2: Qi deficiency;C3: phlegm,blood stasis;C4: Yin deficiency.Correlation analysis has explored 27 groups,which is the support ? 10%,confidence ? 80%.Blood stasis ? phlegm support is 63.49%,and confidence is 100.00%.Blood stasis ? Qi deficiency,phlegm support is 37.42%,and confidence is 100.00%.Phlegm ? lung,blood stasis support is 34.60%,and confidence is 100.00%.Blood stasis ? Qi deficiency support is 59.25%,and the confidence is 81.01%.2.Results of clinical researchThe study can extract the 25 syndrome elements.There are 8 syndrome elements of disease location and 17 nature syndromes of the disease.The main syndrome locations of disease are lung(100.00%),heart(21.15%),spleen(21.15%),kidney(17.31%).Deficiency Syndromes are main Qi deficiency(51.92%),Yang deficiency(38.46%),anemia deficiency(15.38%),Yin deficiency(13.46%).The solidity syndrome evidences are mainly phlegm(59.62%),blood stasis(30.77%),wet(21.15%),fluid retention(17.31%),Qi stagnation(15.38%).There were 7 combinations of nature syndromes of the disease,among which the composition of the double forms of syndrome is the largest,accounting for 36.54%.The composition of the form of one syndrome is 19.23%,which is lower than the double forms of syndrome.Four and five syndrome combinations form is relatively rare.Conclusion: In this study,it use the method of mathematical statistics and four diagnostic information to conclude that: 1.Literature extraction's syndrome elements of disease location is the lung and kidney.It can suggest that the disease first injury is the lung,gradually involving the kidney,and ultimately it can cause simultaneously illness of lung and kidney.Disease nature syndromes of deficiency syndromes in the largest proportion is Qi deficiency.And the deficiencies of Yin and Yang are based on the evolution of Qi deficiency from the change.The formation of Phlegm stasis and phlegm can block the lung's proper function due to Qi stagnation.This data is consistent with the pathogenesis of chronic obstructive pulmonary disease with pulmonary hypertension,which is characterized by chronic,progressive,irreversible and complex.The disease is mixed with emptiness and solidity.Deficiency,phlegm and blood stasis are the reasons of disease delayed lingering and recurrent.2.Questionnaire can also summarize the development of the disease in general order: lung ? heart and spleen ? kidney ? five internal organs.This process happens to be an evil deep process.It is also a process from a single disease syndrome to the development of complex disease syndromes.It reflects the complex of this disease,which is the characteristics of progressive development.