Therapeutic Effect Of Different Analgesic Sedative Complexes On Craniocerebral Traumatic Hyperventilation Syndrome

Purpose: Choose two treatment plans of analgesia and sedation,namely Fentanyl midazolam and Propofol midazolam in order to observe their influence on the hyperventilation syndrome of patients with craniocerebral trauma.Method: Select 40 patients with craniocerebral trauma,with GCS scoring 5 to 8 and Spontaneous breathing too strong(breathing rate > 20 times/m),PaCO2 decrease less than <35mmHg.Randomly divide them into different groups with two analgesic and sedative plans: the group of Fentanyl midazolam and the group of Propofol midazolam.First inject 0.1mg.kg-1 of midazolam into vein and continue to maintain the basic sedation at a constant speed of.0.1mg.kg-1.h-1.15 minutes later,then pump 1ug.kg-1.h-1 of Fentanyl and 1mg.kg-1.h-1 of Propofol into vein at a constant speed.Take the frequency of autonomous respiration <20 times/m and PaCO2 increase >35mmHg as the boundary,and regulate the infusion speed of two medicines at the rate of about 10% every 5 minutes and inject with constant speed until the limit is reached.Observe and record the dosage of two medicines for maintaining the target number within 24 hours as well as the vital signs and the changes of gas blood at the same time.Results: On the basis of realizing basic sedation by midazolam,the routine dosage of two medicines is not able to remedy the symptom of hyperventilation.The dosage of Fentanyl midazolam for getting the target number is 1.32 ug± 0.06 ug.kg-1.h-1 and the time is 71 ±12 minutes.While the dosage of Propofol midazolam for getting the target number is 1.8 mg± 0.6mg.kg-1.h-1 and the time is 42 ±11 minutes.Using Propofol midazolam can achieve the goal in shorter time and the differenct is significant(P<0.05).Propofol midazolam performs better in improving hyperventilation.Inject into vein at a constant speed while maintaining the goal value for two groups.Total injection amount of 24 hours is and Fentanyl midazolam 28.5ug± 0.8ug.kg-1,Propofol midazolam 41.1 mg± 1.9 mg.kg-1,respectively.Fentanyl midazolam leads to more adverse reaction of respiratory depression,and the difference is significant(P<0.05).Conclusion: Patients with craniocerebral trauma,when provided with either Propofol midazolam or Fentanyl midazolam,can both improve the hyperventilation syndrome.But the group of Propofol midazolam can achieve the treatment effects more quickly and much safer.