Effects Of Different Analgesic Regimens On Immune Function In Patients With Craniocerebral Trauma

Objectives:To study the effect of different methods of analgesia on immune function in patients with craniocerebral trauma and theincidence of infection.Methods:All 120 patients with craniocerebral trauma were divided into three groups:group A(40 patients)were treated with Sufentanil 0.3 ?g/kg/h ivgtt and Dezocine 5mg im q8h,group B(40 patients)were treated with Sufentanil 0.1?g/kg/h ivgtt and dezocine 5mg im q8h,group C(40 patients)were treated with dezocine 5mg im q8h.Also,40 healthy people were collected as blank control.Thus,the values of CD4,CD8,CD3 counts in peripheral blood and the ratio of CD4/CD8 were detected and repeated at 3,7,and 15 days after treatment using technology that includes immunochip.Meanwhile,the index volatilities were compared at different times.Additionally,the number of patients with infection including pulmonary infection,urinary tract infection,gastrointestinal infection,and emerging infections were collected in 15 days,and the incidence of infection among all the groups were compared accordingly.Results:The number of CD4 and the ratio of CD4/CD8 in patients of group A,B,and C were significantly lower than that in healthy people of group D(P<0.05).Meanwhile,the number of CD4 and the ratio of CD4/CD8 in patients of group A were significantly higher than that in patients of group B(P<0.05).Also,the number of CD4 and the ratio of CD4/CD8 in patients of group B were significantly higher than that in patients of group C(P<0.05).Overall,there was no significant difference of the number of CD8 among group A,B,C,and D(P>0.05).Additionally,the number of CD3 in patients of group A,B,and C were significantly lower than that in healthy people of group D(P<0.05),while there was no significant difference of the number of CD3 among group A,B,and C(P>0.05).Accordingly,the incidences of postoperative infection in patients of group A and B were both significantly lower than that in patients of group C(P<0.05).Conclusion:Analgesic treatment of Dezocine with or without Sufentanil significantly improved the number of CD4 and the ratio of CD4/CD8 in patients with craniocerebral trauma.This efficacy was significantly increased and the incidence of postoperative infection of patients with craniocerebral trauma was significantly decreased in combination of Dezocine and Sufentanil.