Correlation Between Abnormality Of Thyroid Hormone Levels In Sepsis And TCM Syndromes

Objective:1.By sepsis complicated with abnormal thyroid hormone levels in patients with syndrome differentiation and typing of traditional Chinese medicine,and to monitor the level of thyroid hormone,the results were statistically analyzed,study on sepsis and their thyroid hormone levels anomaly and the relationship between syndrome type of traditional Chinese medicine.2.Through the analysis of sepsis,thyroid hormone level anomaly and the relationship between syndrome type of traditional Chinese medicine,to detect thyroid hormone levels as sepsis syndrome and disease progress indicator,thus contributing to the awareness of sepsis syndromes of traditional Chinese medicine,and improve the ability of type of traditional Chinese medicine diagnosis and treatment of sepsis.Methods:1.Prospective research methods,statistics February 2016-February 2017 admitted to Eastern Hospital and the Beijing traditional Chinese medicine hospital ICU,patients meet the inclusion criteria of 63 cases.Using the method of type of Chinese medicine clinical Basic,four diagnostic information collected,according to the empirical base and fundamental deficiency syndrome diagnostic criteria,divide the patients into deficiency,empirical,with excess and deficiency syndromes.2.After the patient is admitted within the 24h to thyroid hormone testing.3.Record numerical and asthenia,empirical,correlation analysis between syndrome of intermingled deficiency and excess.Data processing and statistical analysis use statistical software SPSS 21.0.Study on sepsis and thyroid hormone level exceptions and the relationship between syndrome type of traditional Chinese medicine.Results:1.Age and sex ratio between the three groups:Age between the three groups does not obey normal distribution,therefore,using non-parametric tests.;comparison of sex ratio of three groups belong to the count data,Chi-square,and x²=6.023,p=0.384>0.05,the difference was not significant.Three groups of patients clinical condition similar to comparable.2.SOFA score and layered between the three groups:SOFA score between the three groups does not obey normal distribution,therefore,using non-parametrictests.x²=2.413,p=0.299>0.05,the difference was not significant;Three groups SOFA score<9 and the SOFA score ? 10 the number using Chi-square test,and x²=13.504a,p=0.001<0.05,there was a significant difference.SOFA score more than 10 points:deficiency syndrome cases the group with the largest number,empirical and syndrome of intermingled deficiency and excess groups were less empirical group least SOFA score ? 9:cases of syndrome of intermingled deficiency and excess group with the largest number,followed by empirical group,virtual group at least.APACHE ? and layered between the three groups:Three groups obey normal distribution,analysis of variance,p =0.411>0.05 of variance,variance,ANOVA tables:p=0.064>0.059?the difference was not significant.Three groups of APACHE ? score ?19 points and number of APACHE ? score ? 20 per cent using Chi-square test,and x²=4.894a,p=0.087>0.05,the difference was not significant.3.Three groups of patients with T₃:Three groups obey normal distribution,analysis of variance,p=0.709>0.05 of variance,variance,ANOVA tables:p=0.000<0.05,there was a significant difference.Pearson correlation analysis,r=-0.711,P=0.000<0.05.The T₃ was negatively correlated with positive-deficiency of syndrome of intermingled deficiency and excess.Three groups FT₃:Three groups do not obey normal distribution,therefore,using non-parametric tests.x²?13.604,p=0.001<0.05,there was a significant difference.Then comparing to the two of three groups of syndromes,including empirical group and compared with syndrome of intermingled deficiency and excess,x²=-2.566,p=0.010<0.05,there was a significant difference;empirical comparison groups and virtual group,x²=-3.312,p=0.001<0.05,there was a significant difference;and deficiency syndrome of intermingled deficiency and excess group,x²=-1.930,p=0.054>0.05,the difference was not significant.Three groups of patients with T₄:Three groups obey normal distribution,analysis of variance,p =0.655>0.05 of variance,variance,ANOVA tables:p=0.000<0.05,there was a significant difference.Pearson correlation analysis,r=-5.398,P=0.000<0.05.The T₄ was negatively correlated with positive-deficiency of syndrome of intermingled deficiency and excess.Three groups of patients with FT₄:Three groups do not obey normal distribution,therefore,using non-parametric tests.x²=1.342,p=0.511>0.05,the difference was not significant.Three groups of patients with TSH:Three groups do not obey normal distribution,therefore,using non-parametric tests.x²=1.209,p=0.546>0.05,the difference was not significant.Conclusions:1.SOFA score may partly reflect severity levels in patients with sepsis,and APACHE II score on type of Chinese medicine syndromes from the empirical-deficiency of syndrome of intermingled deficiency and excess-growth trend,but statistically insignificant.2.Severity of sepsis,T₃ and FT₃,low T₄,FT₄,TSH lower is not obvious,T₃ and FT₃,T₄ levels to reflect degree of sepsis in critical condition,can be used as a clinical indicator of the severity and prognosis of sepsis.3.Sepsis-T₃ and T₄ levels and empirical deficiency of syndrome of intermingled deficiency and excess-there is a negative correlation,deficiency of syndrome and syndrome of intermingled deficiency and excess FT₃ no significant difference,note the body if there is a deficiency syndromes,illness progress very quickly.Clinical reference on T₃ and FT₃,T₄ levels will help to more accurately determine the deficiency and excess syndromes in patients with sepsis.