| Objective1.It is to evaluate the effect of acupoint application on the acute phase of multiple sclerosis by comparison of traditional Chinese medicine treatment of acupoints combined with basic treatment with simple basic treatment program to the clinical efficacy of multiple sclerosis in the acute phase.2.It is proposed innovatively with the theory of Du acupoint sticking based on the theory of multiple sclerosis of TCM pathogenesis understanding,which is to discuss the relevant points to control the development of the external treatment methods and divided by the method of governance.MethodThis study is the main research content of the Beijing Municipal Traditional Chinese Medicine Science and Technology Project based on the pathogenesis of multiple sclerosis acute du meridian sticking method of clinical evaluation.The patients with acute multiple sclerosis were studied.50 patients were randomly included in the random number table method with 25 cases in the treatment group and 25 cases in the control group.It was referred to atrophy syndrome(multiple sclerosis)traditional Chinese medicine treatment program syndrome differentiation program as a basic treatment program for research and design.The treatment group was treated with the basic treatment plan combined with acupoint application of the external treatment,the control group using the basic treatment program.Acupoint application method were used Qingli wet cloud and kidney yang two treatment with the prescriptions used rationale parallel state contained in the water paste and Fuyang Yi Fu cream addition and subtraction according to the multiple sclerosis of the kidney-based,hot and humid as the standard Chinese medicine pathogenesis theory.Line water paste was stick in the Dazhui.Tao Road,body pillars.Fuyang Yi Huo paste was stick on both sides of Shenshu,life door,Yaoyang off,two feet at the end of Yongquan.It was applied once a day,each 4 to 6 hours,a total of paste for 28 days.Clinical evaluation was performed at 3 points on the 14th day and the 28th day,respectively.The neurological function and quality of life of patients with multiple acute sclerosis were evaluated by NIHSS score,EDSS score and Barthel index and clinical common symptom score.Result1.Basic information:In this study,a total of 53 patients were included,3 cases were lost due to live in the field not being scheduled follow-up.50 cases were included in the statistical analysis.25 cases in the treatment group and 25 cases in the control group finally.The average age of the treatment group was 40.76±10.787 with 19 females and 6 males.The average age of the control group was 38.56±11.132 with female 19 and male 9.Two groups were women 38 cases and 12 males.Female to male ratio was 3.2:1.There was no significant difference in sex,age,ethnicity,educational level and occupational demographic data between the treatment group and the control group(P>0.05)..There was no significant difference in infection history,smoking history,drinking history,diabetes,stroke,hyperlipidemia and other medical history and syndromes,physical and other basic information before the onset between the treatment group and control group.2.NIHSS score change results-The scores of the treatment group were 4.0(3.0),and the score was 3.4(4.0)on the 28th day,down with 1.0(2.5),and the difference was statistically significant(P<0.01).The scores of the control group were 3.0(4.0)on the day of the group and 3.0(2.0)on the 28th day,down with 1.0(2.0),and the difference was statistically significant(P<0.05).The total score of NIHSS on the 14th day and the 28th day of the treatment group were compared with the control group.There were no significant differences between the two groups.The pairwise comparison of treatment group was divided into the 14th day,the 28th day of the group with the very day of the group.And the comparison of control group was divided into the 28th day with the very day of the group.The results were significant differences.3.EDSS Score change results:Treatment group scored on the very day by 11.08±4.564 and the score on the 28th day by 5.24±3.407,which decreased by 5.840±3.793.The difference was statistically significant(P<0.01).Control group scored on the very day by 11.80±5.008 and the score on the 28th day by 6.76±3.407,which decreased by 5.040±3.780.The difference was statistically significant(P<0.01).There was significant difference between the treatment group and the control group on the 14th day.There was no significant difference on the 28th day.There were statistically significant differences in the parity between the control group and the control group on the 28th day of the group and the very day of the group.4.Barthel index score change results:Treatment group scored on the very day by 80.0(25.0)and the score on the 28th day by 90.0(17.5),which increased by 10(17.5).The difference was statistically significant(P<0.01).Control group scored on the very day by 80.0(32.5)and the score on the 28th day by 85(27.5),which increased by 5.0(15.0).Differences were statistically significant(P<0.01).There was a statistically significant difference between the treatment group and the control group on the 14th day of admission and the very day of admission in Barthel index score difference.There were significant differences between the treatment group on the 14th day and the 28th day of admission and the very day of admission and the control group on the 28th day of admission and the very day5.Improvement of common clinical symptoms:There were differences in limb weakness,vision disorder,two obstacles,abnormal feeling,slurred speech,ataxia,limb pain and dizziness in the treatment group before and after the treatment.Differences were statistically significant(P<0.05).There were differences in limb weakness,two obstacles,abnormal feeling,ataxia and dizziness in the control group before and after the treatment.Differences were statistically significant(P<0.05).There was no significant difference between vision disorder,slurred speech and limb pain before and after the treatment(P>0.05).There was a significant difference in symptom score between the treatment group and the control group in the three clinical symptoms of limb weakness,vision disorder and abnormal feeling of the 28th day group.Differences were statistically significant(P<0.05).6.Analysis of clinical efficacy:Treatment group of 25 cases,markedly effective in 17 cases(68%),effective in 6 cases(24%),ineffective in 2 cases(8%),the total effective rate of 92%,The control group of 25 cases,markedly effective in 9 cases(36%),effective in 12 cases(48%),4 cases(16%),the total effective rate of 84%,Differences were statistically significant(P<0.05).Conclusion1.Chinese medicine outside the acupoint application method can significantly improve the degree of neurological deficits in patients with acute phase,improve clinical symptoms,improve quality of life combined with pathogenesis in the acute sclerosis of acute medical treatment based on the basis which provides a new method and idea for the clinical treatment of acute sclerosis.2.It is proposed innovatively that medical dialectical treatment combines with surgical sub-division(Du)treatment based on the theory of pathogenesis of multiple sclerosis in acute stage which traditional Chinese medicine elements and plays a characteristics in curing difficult diseases of traditional Chinese medicine.3.Acupoint application is of the exact effect,simple operation and reducing the cost of multiple sclerosis treatment and of patients with higher compliance,which is conducive to the promotion of clinical application at the grassroots level. |
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