| IBS-D (Diarrhea-predominant Irritable bowel syndrome) and UC (ulcerative col itis) are two different diseases; they sometimes have a certain similar clinical manifestation, and UC often shown as IBS in the early and paracmasia phase. Relationship between IBS-D and UC has received wide attention in recent years. Objective:By comparing and discussing the syndrome characteristics of IBS-D and UC, to get inside view of the disease with disease and disease with syndrome relationship between IBS-D and UC and to make futher analysis into the etiology and pathogenesis, the study hopes to offer a way of thinking and feasible therapeutic methods. Methods:80cases of IBS-D patient and80cases of UC patient are studied by questionnaire, medical records taking, and observation on the general information, the symptom and the four examinations. The data are analyzed with SAS8.0software. The measurement data takes normality test, normal distribution data is described in mean and standard deviation(x±s), and skewed distribution data is described in the median, quartile range (M, Q). Taking group comparison.the enumeration data takes Chi-square test. The measurment data chooses values of multiple independent variances and is tested by Kruskal-Wallis H test (KWH). The test level is a=0.05and takes two-sided test. It has statistical meaning when P<O.05and has significant difference when p<0.01. Observation:80cases of IBS-D patient are observed in this research, among which45cases are male and35cases female and the ratio is1.286:1. The age of the80patients ranged from22to70, in non-normal distribution, Q1, M, and Q3are respectively31,41and67. There are two peak age brackets in the clinic patients, the adolescents and the old,18-30years group accounting for23.75%of the total,31-40years26.25%,51-60years30%. There is no association between gender distribution and age distribution. The patients with IBS-D have a long course, averagely8.83±8.64years,6-10years’patients have the highest percentage(40.00%), then1-5years’patients(36.25%). Common causative factors are in order of dietary irregularities (43.75%), climatic evils (33.75%), emotional stress (25%), and taxation fatigue (10%).The symptoms which the occurrence frequency is more than45%are diarrhea, abdominal pain, defecation urgency, poor stool, borborygmus, thirst, lassitude, lower abdomen pain, insomnia, nocturnal, tingling, abdominal fullness and distention, swollen head, belching, poor appetite and indigestion. Inspecting the form of the tongue we can find that47.5%patients with normal tongue shape,46.25%patients with enlargement tongue. To the color of the tongue,38.75%patients with pale red tongue,26.25%dark red,15%dim. To the tongue coating,21.25%patients wear normal thin white coating and73.75%with slimy coating. The results of differentiation show that stagnation of liver-Qi with spleen Qi deficiency is most common (40%), then the weakness of the spleen and the stomach (36.25%). There is no difference of the main pattern of syndrome in different sex, age and course groups.80cases with UC are observed in this research, among which38cases are male and42female, the ratio is1:1.162. The age of the80cases ranged from18to70, mean42.125, standard deviation14.094,31-40years group is most common, accounting for32.5%of the total. There is no association between gender distribution and age distribution. The patients usually have a long course, averagely6.8025±6.8103years,1-5years’patients has the highest percentage(57.00%). Common causative factors are in turn:emotional stress (53.75%), dietary irregularities (51.25%), taxation fatigue (41.25%), and climatic evils (30.00%).List the symptoms of which the frequency is not less than45%are diarrhea, abdominal pain, lassitude, borborygmus, blood purulent stool, abdominal chills, thirst, bloating, tenesmus, defecation urgency, poor appetite and indigestion, abdominal stuffiness, pale complexion, anal burning, fecal incontinence.Inspecting the color of the tongue can we see that dim tongues occur most (32.5%), then the dark red ones27.5%, red ones16.75%, pale ones10%. To the tongue coating, yellow slimy coating and white slimy coating are the most common,28.75%.26.25%, then the thin white coating20%, the thin yellow coating18.75%. The results of the pulse examination suggested that the fine pulse is most common; accounting for reach up to73.75%, then the slippery pulse62.5%. The results of differentiation show that the most common pattern is damp-heat of large intestine (37%), then the kidney yang deficiency23%. There is no difference of the main pattern of syndrome in different sex, age and course groups.To compare the general information of IBS-D with UC, there is no significant difference in gender, age, duration and distribution. For the common causative factors in multiple comparison, the two has no significant difference in dietary irregularities, emotional stress and climatic evils. Compared to IBS-D, the patients with UC are easier to aggravate the symptom caused by excess fatigues.To compare the abnormal defecation of the two diseases, we can find that both of them mainly manifest in diarrhea and abdominal pain. Patients with IBS-D are easier to suffer the defecation urgency and poor stool, and patients with UC are more likely to have tenesmus, blood purulent stool, and anal burning. To compare the constitutional symptom of the two can we see that there is no significant differences between the two diseases in respect to abdominal pain, bloating and abdominal stuffiness. Symptoms like abdominal chills, borborygmus, poor appetite and indigestion, fatigue in two diseases are obviously different. Comparatively speaking, patients with UC have more serious constitutional symptom.The comparison of the tongue between the IBS-D and UC shows that patients with IBS-D are more likely to have normal tongue. For the abnormal tongue, UC patients are more likely to per formant as red tongue. Patients with IBS-D wear more white slimy coating and patients with UC wear more yellow slimy coating.Through comparison of the main patterns of the IBS-D patients and UC patients, we could get the result that stagnation of liver-Qi with spleen Qi deficiency and weakness of the spleen appear more in the patients of IBS-D, Damp-heat of large intestine and the kidney yang deficiency are more likely to be found in the patients with UC. Conclusions:Both IBS-D and UC patients are mainly manifesting in diarrhea and abdominal pain. Patients with IBS-D are likely to suffer the defecation urgency and poor stool, and patients with UC are more likely to have tenesmus, blood purulent stool, and anal burning. Patients with UC have more serious constitutional symptom. Both the two have the pathogenesis of spleen deficiency, patients with IBS-D are spleen deficiency with dampness, combining liver depression, patients with UC are deficiency of spleen and kidney, combining damp-heat of the large intestine. |
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