| The synthesis,properties and applications of organotin compounds have received considerable attention since their anti-tumor activities was discovered.At present,the studies of amines,the natutral amino acids and acyl hydrazones Schiff Bases as well as their organotin compounds are popular,but the studies of aminoxyaeetic acid salicylaldehgde schiff base and β-amino acid Schiff Bases as well as their organotin compounds have received less attention,although they have strong coordination ability.In recent years,a vast amount of investigations has focused on the organotin compounds of functionalized ligands with additional S or N atom,xanthate is an important family of sulfur compounds,and their reactions with organotin compounds had also attracted attention.This thesis mainly included two section as follow:Section one:The studies of aminoxyaeetic acid and β-amino acid salicylaldehyde Schiff Bases as well as their organotin compounds.1.The studies of aminoxyaeetic acid salicylaldehyde Schiff Bases as well as their organotin compounds.Aminoxyaeetic acid hemihydrochlorid was prepared by the reaction of condensation,substitu-tion and hydrolysis using acetone,hydroxylamine hydrochloride,monochloro acetic acid asra w material.The product was characterized by melting point,1H NMR,IR.Aminoxyaeetic acid salicylaldehyde Schiff Base,aminoxyaeetic acid 3-Methoxysalicylaldehyde Schiff Base,aminoxyaeetic acid 5-chorosalicylaldehyde Schiff Base and aminoxyaeetic acid 5-Nitrosalicyladehyde Schiff Base were synthesised using aminooxy acetic acids hemihydrochlor id,salicylaldehyde,3-Methoxysalicylaldehyde as raw material,and the reactions of aminoxya-eetic acid salicylaldehyde Schiff Base with dialkyl tin dichlorides were studied.The products were characterized by melting point,MS,1H NMR,IR and UV-Vis.2.The studies of β-Alanine salicylaldehyde Schiff Base as well as their organotin compounds.P-Alanine salicylaldehyde Schiff Base,β-Alanine 3-Methoxysalicylaldehyde Schiff Base,β-Alanine 5-chorosalicylaldehyde Schiff Base,β-Alanine 5-Nitrosalicyladehyde Schiff Base were synthesised using β-Alanine,salicylaldehyde,3-Methoxysalicylaldehyde as raw material,and the reactions of β-Alanine salicylaldehyde Schiff Base with dialkyl tin dichloride(Ph,Bu,Me)were studied.The products were characterized by melting point,MS,’H NMR,IR and X-ray single crystal diffraction.Section two:the study of the reaction of diphenyltin dichloride with potassium xanthatePotassium ethylxanthate,Potassium isopropylxanthate,Potassium n-butylxanthate and Potassium Cyclohexyl xanthate were synthesised using KOH,CS2 with ethyl alcohol,iso-Propyl alcohol,n-butyl alcohol and cyclohexanol.The effects of temperature on the reactions of diphenyltin dichloride with potassium xanthate were studied.The effects of solvents and mole ratio on the reaction of diphenyltin dichloride with etyhl potassium xanthate were studied.When n(Ph2SnCl2):n(ROCSSK)=1:2,Ph2Sn(S2COR)2(R=Et,i-Pr,Bu,Hex)were obtained at the low temperature,while(Ph2SnS)3 was obtained at the temperature above stagnation temperature,and the alkyl of potassium xanthate was larger,the stagnation temperature was higer;Ph2Sn(S2COR)2 decomposited to generate(Ph2SnS)3 at the temperature above stagnation temperature.The products were characterized by melting point,MS,1H NMR,IR and X-ray single crystal diffraction. |
