The Fundamental Research On The Efficacy Assessment And Surgical Planning Of Minimally Invasive Tumor Microwave Ablation

Microwave thermal ablation technique with minimally invasive feature has intriguing advantages of small incision,predictable ablation zone and significant therapeutic effect.It is widely used in the clinical treatment of solid tumors such as liver cancer and kidney cancer.The precise preoperative plan and real-time intraoperative therapeutic efficacy assessment during microwave ablation process is one of the most critical problems in clinics.In order to solve above issues,the present study aims at establishing an evaluation system for microwave hyperthermia assessment using the classical temperature field as criterion.In combination with CT imaging technique,a set of preoperative plan system for microwave ablation therapy is developed.The main contents of this paper: 1.For standard needles used in clinics,the microwave ablation simulation model with desirable accuracy and effectiveness was established using the finite element simulation of dynamic biological tissue parameters.Simulation software COMSOL was applied to package the simulation model as a user-friendly simulation App,and afterwards rapid and accurate simulation was performed under various therapeutic dosage;2.The effective temperature field and ablation volume under hyperthermia induced by microwave of various therapeutic dosage were obtained by finite element simulation.A theoretical temperature distribution field model in biological tissues during microwave thermotherapy was thus developed.The simulation results were further verified for their accuracy and effectiveness by comparing with experimental outcomes obtained from ex vivo porcine liver ablation study;3.In order to enable more precise treatment,a microwave ablation software system was designed,embedded with above temperature field model.Moreover,the development of our system was based on the CT imaging technique,and basic functions including image import,3D reconstruction,tumor outline,etc.,can be realized to formulate a proper preoperative plan.The main innovations of this paper: Considering their simultaneous response to the changes of temperature,dynamical thermophysical parameters and electrical parameters were used for theoretical simulation,based on which the temperature field distribution in biological tissues can be obtained more precisely;The temperature field model was obtained from microwave ablation needles which are currently being used in clinics.Therefore,simulation results reported in present study can be easily migrated for clinical use.A complete set of medical imaging software for microwave ablation was developed,allowing for efficient preoperative planning and intraoperative assessment.The results in present study are of great significance for future development of minimally invasive microwave hyperthermia equipment.