The Fundamental Study Of Real-time And Accurate Intracranial Pressure Monitoring Technology

Intracranial pressure(ICP)is one of the most important indexes in the monitoring of postoperative patients after neurosurgery,and the ICP monitoring technology is one of the most important research subjects in medical equipment manufacturers.Manufacturing process precision of ICP probe is highly demanded with a restricted requisite of materials and a high standard for product assembly and packaging.However,available domestic products of ICP monitoring barely meet the above requirements for clinical use.Currently,ICP monitoring facilities in clinics in China mainly rely on the imported products.This paper focuses on the quality control and precise calibration of the ICP probe manufacturing process,while constructing wireless network of the monitoring system.The main research contents and innovative points are as follows:This paper proposed a multi-user ICP monitoring system based on wireless network.Our system includes an ICP probe,a bridge matching unit,a signal acquisition unit,an independent monitoring host unit,wireless network and multi-user monitoring software.This system can provide accurate measurement of ICP of a single patient and allow for ICP monitoring by multiple users spontaneously.Firstly,the stable and reliable ICP signal collection process was established.The full Wheatstone bridge was constituted by a classic half Wheatstone bridge and external resistance network.The Wheatstone bridge served as a transducer to convert pressure signals into differential voltage signals.After differential amplification,voltage signals were then converted into digital signals through an analog-to-digital converter.Next,after the design and manufacture of the probe,performance test and precise calibration were carried out for the probe optimization.Comprehensive performance tests include determining probe baseline drift and parameter drift of electronic components influenced by temperature,and identifying the repeatability and accuracy of ICP measurement.These studies could be valuable for the standardization of batch manufacturing process of ICP probe.A sophisticated calibration system was designed for probe batch calibration,by which optimal parameters for temperature drift compensation can be calculated.The compensation of temperature drift of the probe can thus be achieved and its reliability was verified in vitro experiment.A complete set of multi-user monitoring system was integrated by the use of Zigbee wireless network.A series of data management software was developed,allowing for real-time monitoring of ICP in a maximum of 10 patients.The alarm function of our system provided a timely reminder for the doctors and nurses in real-time.Corresponding ICP data can be conveniently saved for later statistical analysis or medical research.Fabrication process of ICP monitoring probe was further optimized in present study to meet the requirements of both accurate ICP measurement and product manufacture on a large scale.The measurement accuracy and stability of our probe reached the standard for clinical application,which laid a solid foundation for future domestic manufacturing of ICP monitoring system in China.