Effects Of Adapted Aquatics On Behavior And Serum Level Of Interleukin In Autistic Children

Objective:By observing changes of serum levels of interleukin in children with autism before and after 4 weeks of adapted aquatics,and to investigate the intervention mechanism of adapted aquatics in children with autism to provide evidence-based support for children with autism.Methods:14 boys with autism in Guangzhou were selected as subjects,aged 4 to 10 years old.According to the CARS scale,14 subjects were randomly divided into experimental group and control group,each group of 7 people.The experimental group for 4 weeks of regular adapted aquatics,five times a week,90 minutes each time,the control group for daily life mode.Time to take the subjects’ samples: 7:30-8:00 am(in the state of be calm and no breakfast),Serum levels of IL-1β,IL-2R,IL-4,and IL-6 were detected by enzyme-linked immunosorbent assay(ELISA)before and after the intervention.Results:1.After adapted aquatics intervention of experimental group,the body movement(before intervention: 6.556±6.401;after intervention: 4.4447±5.501)and self-care ability(before intervention: 9.556±6.061;after intervention: 7.278±5.633)of the autistic behavior rating scale(ABC)had decreased than before intervention,and there was significant difference(P <0.05);but sensation(before intervention: 9.83±7.326;after intervention: 9.111±5.572),social interaction(before intervention: 10.889 ± 8.858;after intervention: 9.50 ± 8.001),language(before intervention: 12.833 ± 7.422;after intervention: 12.222 ± 8.981)and total score(before intervention: 49.66 ± 28.506;after intervention: 42.556 ± 26.27)of the autistic behavior rating scale(ABC)were decreased than before intervention,but there was no significant difference(P > 0.05).2.After adapted aquatics intervention of control group,the body movement(before intervention: 8.357±7.239;after intervention: 11.214±7.392)of the autistic behavior rating scale(ABC)had increased than before intervention,and there was significant difference(P <0.05);but sensation(before intervention: 10.429±5.543;after intervention: 11.571±5.867),social interaction(before intervention: 11.571±7.165;after intervention: 12.357±6.368),language(before intervention: 8.786±7.106;after intervention: 11.143±8.113),self-care ability(before intervention: 8.571±3.715;after intervention: 10.929±4.323)and total score(before intervention: 47.714±25.436;after intervention: 57.214±23.671)of the autistic behavior rating scale(ABC)were increased than before intervention,but there was no significant difference(P > 0.05).3.After adapted aquatics intervention,the experimental group and control group autism behavior scale difference comparison shows that the body movement(experimental group:-2.11±2.928;control group: 2.86±4.865),self-care ability(experimental group:-2.28±3.659;control group: 2.36±5.372)and total score(experimental group:-7.11±15.465;control group: 9.50±16.842)score was very significant difference(P< 0.01);sensation(experimental group:-0.72±5.539;control group: 1.14±3.939),social interaction(experimental group:-1.39±4.742;control group: 0.79±4.336)and language(experimental group:-0.61±6.391;control group: 2.36±5.826)score there was no significant difference(P > 0.05).4.After adapted aquatics intervention of experimental group,IL-1β(before intervention: 14.213±0.185;after intervention: 13.984±0.204)and IL-4(before intervention: 19.257±1.363;after intervention: 18.711±1.113)had decreased than before intervention,and there was significant difference(P <0.05);IL-2R(before intervention: 703.744±280.644;after intervention: 562.391±203.789)and IL-6(before intervention: 27.667±10.343;after intervention: 14.414±14.267)had decreased than before intervention,but there was no significant difference(P > 0.05).5.After adapted aquatics intervention of control group,IL-1β(before intervention:14.086±0.554;after intervention: 14.290±0.404),IL-4(before intervention: 19.010±1.251;after intervention: 19.035±1.048)and IL-6(before intervention: 20.212±7.396;after intervention: 22.366±6.533)were increased than before intervention,but there was no significant difference(P > 0.05);IL-2R(before intervention: 836.075±218.336;after intervention: 754.120±213.800)had decreased than before intervention,but there was no significant difference(P >0.05).6.After adapted aquatics intervention,the experimental group and control group serum level of interleukin difference comparison shows,IL-4(experimental group:-0.912±0.506;control group: 0.025±0.239)levels have significant difference(P < 0.05);IL-1β(experimental group:-0.229±0.210;control group: 0.204±0.723),IL-2R(experimental group:-141.353±187.500;control group:-81.955±130.021)and IL-6(experimental group:-13.254±16.049;control group: 2.154±6.606)there was no significant difference(P > 0.05).Conclusion1.Adapted Aquatics can improve autistic children’s body movement and self-care ability.2.Adapted Aquatics can significantly reduce serum levels of IL-1β and IL-4 in children with autism.3.Adapted Aquatics may reduce serum level of IL-1β to improve autistic children’s body movement.