The Study On The Relationship Between Autonomic Nervous Function And Atherosclerosis In Patients With Primary Hypertension In Qinghai Area

Objective: Synchronic dynamic electrocardiography and ambulatory blood pressure monitoring are performed in patients with primary hypertension to investigate the relationship between autonomic nerve function and atherosclerosis.Methods: A total of 120 patients with primary hypertension who were admitted to Qinghai University Affiliated Hospital from October 2016 to October 2017.The clinical data of all subjects were collected,including medical history,general information and biochemical examination.Then synchronic dynamic electrocardiography and ambulatory blood pressure monitoring were performed for all patients.The Heart Rate Variability were detected by dynamic electrocardiography.The Blood Pressure and the Blood Pressure Circadian Rhythm were detected by ambulatory blood pressure monitoring.Using ambulatory arterial stiffness index(AASI)to assess the degree of atherosclerosis.Subjects were divided into normal AASI group(AASI<0.55)and abnormal AASI group(AASI ? 0.55)according to AASI values.Results:1.Comparison of nocturnal blood pressure drop rate between the two groups: The nocturnal blood pressure drop rate between the two groups showed no significant difference(p>0.05).2.Comparison of clinical data between the two groups: Compared with normal AASI group,the course of hypertension was significantly longer in abnormal AASI group(p<0.05).The other indicators showed no significant difference(p>0.05).3.Comparison of heart rate variability between the two groups:Compared with normal AASI group,the standard deviation of average R-R interval during every 5 minutes significantly decreased,while the low frequency and low frequency / high frequency increased,which there were statistical significance(p<0.05).4.Binary Logistic regression analysis showed that the course of disease,low frequency and low frequency / high frequency were independent risk factors for AASI.(p<0.05).Conclusion:1.The longer the course of hypertension,the higher the probability of occurrence of atherosclerosis.2.The heart rate variability decreased,suggesting that autonomic nerve function is associated with atherosclerosis in patients with primary hypertension.3.Autonomic nervous system dysfunction,especially the sympathetic nervous system activity is an independent factor that promotes the occurrence and development of atherosclerosis in patients with primary hypertension,and so do the course of disease.