| Objective:We analyzed the risk factors of the migraine to make clear that the potential risk factors associated with migraine of the cerebral small vessel diseases(CSVD)among the middle-aged and young female in Xining region to prevent the related diseases.Methods:126 middle-aged and young female patients were selected as the research object,who was treated in the affiliated hospital of Qinghai university from November 2016 to February 2018.The case group was made up of 60 patients,who were definitely diagnosed as migraine.The control group consisted of 66 patients,who conformed to the compared standard.We analyze the risk factor of migraine after collecting and organizing general information of all subjects.All the patients underwent the brain magnetic resonance image(MRI).According to the result of the examination,the migraine groups were divided into two subgroups:the CSVD subgroup and the non-CSVD subgroup.We analyzed the occurrence of CSVD among the subgroups to explore the relationship between the migraine and the CSVD.Results:1.The mobidity rate of hypertension and heart disease and the proportion of the patients with family history of the migraine in the migraine group were higher than that in the control group(21.67%vs9.09%,30.00%vs9.09%,46.67%vs10.60%),with statistical differences between the two groups(P<0.05);Multivariate logistic regression show that family history of migraine and hypertension were the risk factor of migraine(P<0.05).2.The mobidity rate of CSVD in the migraine group was40.00%,and the mobidity rate of CSVD in the control group was 21.21%,with statistical difference(P<0.05).The mobidity rate of lacunar infarction(LI)was91.67%and 50.00%respectively,with statistical difference(χ~2=8.493,P=0.004).3.The mobidity rate of migraine aura,the proportion of the patients with family history of migraine and the points of the numerical rating scale(NRS)over 4 in the CSVD subgroup were higher than that in the non-CSVD subgroup(41.67%vs5.56%,62.50%vs36.11%,75.00%vs22.22%),with statistical(P<0.05).4.CSVD subgroup was compared with non-CSVD subgroup,we found that the history of migraine,duration and frequency of attack,the median number respectively were 6.00vs3.00,19.00vs18.50 and 8.00vs7.00.Among which the history existed statistical difference(U=194,z=-3.620,P=0.000).5.Multivariate logistic regression showed that the medical history of migraine,migraine with aura and the points of the NRS over 4were the risk factors of CSVD(P<0.05).Conclusion:1.The family history of migraine and the hypertension are the risk factors of migraine among the middle-aged and young female in Xining region.2.The factors that affect the occurrence of CSVD are migraine with aura,history of migraine and the degree of headache among the middle-aged and young female patients of migraine in Xining region.3.Migraineurs are prone to the CSVD,which is more common in LI. |
