Relationship Between Serum Uric Acid And The Imaging Features Of Cerebral Small Vessel Diseases

Objective To investigate the relationship between serum uric acid and the imaging features of cerebral small vessel diseases(lacunar infarction, white matter hyperintensity, cerebral microbleeds and enlarged perivascular spaces).Methods From January 2014 to December 2015, a cross-sectional study was conducted at the Department of Neurology of the First Hospital of Fujian Medical University. All cerebral small vessel diseases admitted to hospital with two or more imaging features were recruited into this study. The patients were divided into group according to the severity of lacunar infarction, white matter hyperintensity, cerebral microbleeds and enlarged perivascular spaces. Serum uric acid and the incidence of hyperuricemia were compared between groups, and risk factors for severe imaging features of cerebral small vessel diseases were analyzed with multivariate Logistic regression models.Results 197 patients of cerebral small vessel diseases were enrolled into this study. serum uric acid and the incidence of hyperuricemia were higher in severe LI group( P =0.002), severe DWMH group( P =0.010),severe CMBs group( P =0.043) than in other subgroup, while age(odds ratio [OR] 1.072, 95% confidence interval [CI] 1.035~1.110, P=0.000), serum uric acid(OR1.004, 95%CI 1.001~1.007, P=0.014), hypertension( OR 2.410, 95% CI 1.175~4.944, P =0.016) were independent risk factors for severe deep WMH after adjustment for diabetes, serum lipid and smoking,drinking history.Conclusion These data suggest that serum uric acid is an independent risk factor for severe deep WMH in patients of cerebral small vessel diseases and have no significant relationship between serum uric acid and lacunar infarction, cerebral microbleeds, enlarged perivascular spaces.