Clinical Comparative Study Of Atorvastatin Versus Rosuvastatin In Patients With CHD After PCI In High Altitudes

Objective: By tracking the changes of preoperative and postoperative blood lipid,liver function,renal function,muscle enzymes,blood glucose and other indexes in patients who undergoing percutaneous coronary intervention(PCI),comparative the relationship two common statins,atorvastatin and rosuvastatin,in patients with coronary heart disease in high altitude clinical role,in order to clinicians in the choice of two drugs provide a reference.Object and Method: A total of 101 patients with coronary heart disease undergoing PCI at the Department of Cardiology,Affiliated Hospital of Qinghai University from 2015.11 to 2016.06 were randomly divided into two groups: atorvastatin group and rosuvastatin group.Atorvastatin group(group A): 80 mg loading dose atorvastatin preoperatively and 20 mg / d postoperatively were given.The patients in rosuvastatin group(R group)were given the loading dose Rosuvastatin 20 mg preoperatively,postoperative 10 mg / d.Through on-site follow-up and telephone reminder,the main indexes such as blood lipid,blood glucose,liver,kidney function and muscle enzyme were monitored before operation,3 months and 6 months after operation,and compared effect and safety of two statins on coronary heart disease patients after PCI in high altitude areas.Results: Atorvastatin group and rosuvastatin group before PCI had no significant difference in the baseline conditions and other indexes of lipids,liver function,renal function,muscle enzymes and blood glucose before PCI(P> 0.05).In contrast to before treatment,the two groups of patients at 3 and 6 months after PCI,the level of blood lipids improved and liver function,renal function,muscle enzymes,blood glucose and other indicators have no significant difference.The comparison of the two groups showed that the R group had better regulation of blood lipids than the A group,the difference was statistically significant(P <0.05).Conclusion: Statins have a positive lipid-lowering effect on patients with coronary heart disease after PCI at high altitudes,with no significant difference from the reported levels in plain areas.Rosuvastatin treatment are more effective than atorvastatin.Both drugs have high safety for patients after PCI in high altitude area and can be used for a long time.