| Objective: To investigate the effect of obstructive sleep apnea syndrome on cognitive function in stroke patients.Methods:Fifty patients with acute ischemic stroke were enrolled in Department of Neurology,Peking University Medical Hospital,June 2015-June 2016,50 patients with no acute stroke were enrolled in the examination center,and 25 patients were OSAS with acute ischemic stroke,25 patients with OSAS and non-acute stroke,25 patients with non-OSAS and acute ischemic cerebral infarction,and 25 patients with non-OSAS and non-acute stroke.Recording the general condition of the patient,carrying out themini mental status examination,and the Montreal cognitive assessment to evaluate the cognitive function.All patients were examined by polysomnography,and the apnea index was recorded separately.Application of statistical software analyzes OSAS group and non-OSAS group in general,comparing the difference of OSAS group and non-OSAS group in the total score of cognitive function,the difference of cognitive function between the dangerous degree in stroke patients with OSAS,and whether there was interaction between OSA and OSAS on cognitive function.Results:The mean neck circumference of the OSAS group of stroke patients was41.16 ± 2.86(cm),the mean neck circumference of the non-OSAS group of stroke patients was 38.12 ± 1.48(cm),the P value was 0.000,the average waist circumference of the OSAS group of stroke patients was 100.88 ± 6.55 cm,the average waist circumference of the non-OSAS group of stroke patients was 97.16 ± 3.90(cm),P value was 0.018;the two groups of patients with neck circumference,waist difference was statistically significant(P <0.05).The mean neck circumference of the OSAS group of non-stroke patients was 40.27 ± 2.06 cm,the mean neck circumference of the non-OSAS group of non-stroke patients was 37.00 ± 1.08(cm),the P value was 0.000;the average waist circumference of the OSAS group of non-stroke patients was 98.16 ± 5.42(cm),the non-OSAS average waistline of non-stroke patients was 96.10(P <0.05).2.The MMSE score of OSAS group was 22.56 ± 5.33 and 26.12 ± 4.12 in the non-OSAS group,the P value was 0.011,the Mo CA score in the OSAS group was 21.64 ± 4.76,and the Mo CA score in the non-OSAS group was : 24.36 ± 3.72,P value was 0.029.The differencebetween the two groups was statistically significant(P <0.05).3.The score of MMSE in OSAS mild group was 28.78 ± 1.30 and 20.80 ± 1.48 in OSAS moderate group,MMSE score of OSAS severe group was 16.17 ± 2.23,The score of Mo CA in OSAS mild group was 26.78 ± 1.30,Mo CA score of moderate OSAS group20.27 ± 1.83,OSAS severe group Mo CA score of 15.50 ± 2.36.MMSE score of three groups were statistically significant(P <0.05),Mo CA score of three groups were significantly different(P <0.05).4.With the increase of neck circumference and waist circumference,the cognitive function showed a decreasing trend.5.The F value of OSAS was 23.2 74,P value of 0.000,stroke F value of 34.318,P value of 0.000,OSAS * stroke F value of 0.082,P value of 0.775.OSAS,stroke,respectively,affect the cognitive function,There is no interaction between stroke and OSAS on cognitive function.Conclusion : OSAS can aggravate the cognitive dysfunction in stroke patients,which can increase with the severity increased,and is also affected by the increase of cervical circumference and waist circumference.Although stroke and OSAS have an impact on cognitive function,but there is no interaction between the two. |
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