Expression And Clinical Significance Of Twist?CD44 And CD24 In Breast Cancer

Objective:To study the expression and clinical significance of Twist,CD44 and CD24in breast cancer.Methods:Human breast tissues were obtained from 88 female patients with sporadic breast disease,including 30 cases of breast cancer tissue,30 cases of paracancerous tissues and 28 cases of breast fibroma,who underwent surgery at the Affiliated Hospital of Zunyi Medical College between 2016 and 2017.The expression of Twist,CD44 and CD24 were detected with the method of enzyme-linked immunosorbent assay and the correlation with clinical data was analyzed respectively.Results:The Twist level in the breast cancer group was higher than that in the paracancer group and the fibroid group(P<0.05),but the fibroid group was not significantly different from that in the paracancer group(P>0.05).The levels of CD44 in the breast cancer group were higher than those in the paracancer and fibroid groups(P<0.05),and the CD44 levels in the fibroid group were higher than those in the paracancer group(P<0.05).The levels of CD24 in the breast cancer group were higher than those in the paracancer group and fibroid group(P<0.05),and the fibroid group was higher than that in the paracancer group(P<0.05).The expression of Twist was positively correlated with Ki-67(r_s=0.345,P=0.006),which was not associated with age,lymph node metastasis,menstrual status,ER,PR,Her-2,TNM stage,and pathological grade(P>0.05).There was a positive correlation between CD44 and Her-2(r_s=0.091,P=0.018),which was independent of age,lymph node metastasis,menstrual status,ER,PR,TNM stage,pathological grade,and Ki-67(P>0.05);CD24 was related to lymph node metastasis(r_s=0.209,P=0.017)and Her-2(r_s=0.325,P=0.014),which was independent of patient age,menstrual status,ER,PR,TNM staging,pathological grade,and Ki-67(P>0.05).Conclusion:1.The levels of Twist,CD44,and CD24 in breast cancer tissues were higher than those in adjacent tissues detected from protein levels,suggesting that the three may be related to the occurrence of breast cancer.2.According to correlation analysis,the expression of Twist,CD44,CD24 was associated with some clinical features,suggesting that the combined detection of the three may have certain clinical significance for the diagnosis,treatment,high-risk population screening,evaluation of prognosis and so on.