The Reevaluation Of Pulmonary Function Parameters In The Diagnosis Of Chronic Airway Inflammatory Disease

Objective:To study the clinical value of lung function test parameters such as lung ventilation function,lung capacity function and lung dispersion function in differential diagnosis and disease stage of common chronic airway inflammatory diseases such as bronchial asthma(BA)and chronic obstructive pulmonary disease(COPD).Methods:The medical records and lung function test of 100 cases of patients with BA and 100 cases of patients with COPD hospital or outpatient treatment in the first affiliated hospital of zhejiang university medical college from January 2016 to December 2016 were retrospective analyzed.BA patients were divided into acute phase(n=32 cases),chronic duration(n=35 cases)and remission(n=33 cases),COPD patients were divided into acute phase(n=55 cases)and stability(n=45 cases).The pulmonary ventilation function indexes(VC,FEV1,FVC,FEV1/FVC,PEF and MMEF),lung capacity function indexes(RV,TLC and RV/TLC)and lung dispersion function(DLCO and DLCO/VA)were detected by Masterscreen PFT lung function instrument.SPSS 16.0 statistical software was used to carry out data statistics and analysis.Results:The pulmonary ventilation function indexes such as VC,FEV1,FVC,FEV1/FVC,PEF,MMEF of BA group were significantly higher than that of COPD group(P<0.05).The lung capacity function indexes such as RV,RV/TLC of COPD group were significantly higher than that of BA group(P<0.05),while there was no significant difference between the two groups about TLC(P>0.05).The lung dispersion function indexes such as DLCO,DLCO/VA of BA group were significantly higher than that of COPD group(P<0.05).There was a significantly difference between various clinical staging in BA group about VC,FEV1,FVC,FEV1/FVC,PEF,MMEF(P<0.05),and with the progress of the acute phase,chronic duration,remission,the pulmonary ventilation function indexes were significantly higher(P<0.05).There was a significantly difference between various clinical staging in COPD group about VC,FEV1,FVC,FEV1/FVC,PEF,MMEF(P<0.05),and with the progress of acute phase,stability,the pulmonary ventilation function indexes were significantly higher(P<0.05).There was a significant difference between different clinical staging in BA group about RV,RV/TLC(P<0.05),while there was no significant difference about TLC(P>0.05),and with the progress of the acute phase,chronic progress duration,remission,the lung capacity function indexes(except TLC)significantly decreased(P<0.05).There was a significant difference between different clinical staging in COPD group about RV,RV/TLC(P<0.05),while there was no significant difference about TLC(P>0.05),and with the progress of acute phase,stability,the lung capacity function indexes(except TLC)significantly decreased(P<0.05).There was a significant difference between different clinical staging in BA group about DLCO,DLCO/VA(P<0.05),and with the progress of acute phase,chronic,duration,remission,the pulmonary diffusion function indexes increased significantly(P<0.05).There was a significant difference between different clinical staging in COPD group about DLCO,DLCO/VA(P<0.05),and with the progress acute phase,stability,the diffuse lung function indexes increased significantly(P<0.05).Conclusion:Lung function test can diagnose and distinguish BA and COPD in time.The dispersion function is more important to distinguish these two diseases.It is also important to assess the stages,treatment and prognosis of these two diseases.