Establishing Reference Intervals Of Gastrin-releasing Peptide Precursor By Analysis Of Laboratory-stored Data

Objective : To establish and verify the feasibility of reference intervals(RIs)of gastrin-releasing peptide precursor(ProGRP)by analysis of laboratory-stored data.Methods:The detection results of ProGRP from outpatients and health examinations were collected from the population in the First Hospital and Tumor Hospital Affiliated to Xinjiang Medical University from January 2015 to December 2016.Simultaneously,the general characteristics of the population were collected using a laboratory information management system.A total of 16384 ProGRP cases were collected.All ProGRP tests were measured using Abbott fully automated microparticle luminescence analyzer.The ProGRP RIs of different sexes and ages were established by differentially optimized statistical methods,which included the Hoffmann method,the NLT Hoffmann method(in which the natural logarithm was calculated first and then the Hoffmann method was performed),the Tukey method,the NLT Tukey method(in which the natural logarithm was calculated first and then the Tukey method was performed),and the non-parametric method.Results:There were no significant differences in the ProGRP results between males and females(P>0.05).The ages were positively correlated with the measured value of the ProGRP(R=0.342,P<0.05),which could be grouped according to ages.The established RIs of ProGRP in this study was 8.53-67.575 pg/ml.Conclusion:According to different statistical methods,we established the RIs of ProGRP in this study,which will be of certain reference value to the future laboratory studies.